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EPS8L3 EPS8 like 3 [ Homo sapiens (human) ]

Gene ID: 79574, updated on 8-Dec-2018

Summary

Official Symbol
EPS8L3provided by HGNC
Official Full Name
EPS8 like 3provided by HGNC
Primary source
HGNC:HGNC:21297
See related
Ensembl:ENSG00000198758 MIM:614989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPS8R3
Summary
This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 73.4), duodenum (RPKM 70.1) and 4 other tissues See more
Orthologs

Genomic context

See EPS8L3 in Genome Data Viewer
Location:
1p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (109750080..109764022, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110292702..110306644, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 5 Neighboring gene glutathione S-transferase mu 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 10 Neighboring gene long intergenic non-protein coding RNA 1768

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21522, MGC16817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to Rac guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT Rac guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of hair cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
epidermal growth factor receptor kinase substrate 8-like protein 3
Names
EPS8-like protein 3
EPS8-related protein 3
epidermal growth factor receptor pathway substrate 8-related protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319952.1NP_001306881.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate 5' exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AK025175, AK307932, AL158847, CB159338
    UniProtKB/Swiss-Prot
    Q8TE67
    Conserved Domains (3) summary
    cd11764
    Location:392444
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:1120
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    cl15755
    Location:461526
    SAM_superfamily; SAM (Sterile alpha motif )
  2. NM_024526.3NP_078802.2  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform c

    See identical proteins and their annotated locations for NP_078802.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK025175, AK225235, AK290261, AW937714, BM797626, BM824107, CB159338, DA927692
    Consensus CDS
    CCDS813.1
    UniProtKB/Swiss-Prot
    Q8TE67
    UniProtKB/TrEMBL
    A8K2J6
    Related
    ENSP00000354551.4, ENST00000361852.8
    Conserved Domains (3) summary
    cd11764
    Location:425477
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:25154
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    cl15755
    Location:494559
    SAM_superfamily; SAM (Sterile alpha motif )
  3. NM_133181.3NP_573444.2  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform b

    See identical proteins and their annotated locations for NP_573444.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AK292198, AY074930, BM737806, BM824107, CB159338
    Consensus CDS
    CCDS814.1
    UniProtKB/Swiss-Prot
    Q8TE67
    Related
    ENSP00000355255.4, ENST00000361965.8
    Conserved Domains (3) summary
    cd11764
    Location:455507
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:25154
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    cl15755
    Location:524589
    SAM_superfamily; SAM (Sterile alpha motif )
  4. NM_139053.2NP_620641.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform a

    See identical proteins and their annotated locations for NP_620641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC012926, BM737806, BM824107, BP419077, CB159338
    Consensus CDS
    CCDS815.1
    UniProtKB/Swiss-Prot
    Q8TE67
    Related
    ENSP00000358820.3, ENST00000369805.7
    Conserved Domains (3) summary
    cd11764
    Location:456508
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:25154
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    cl15755
    Location:525590
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    109750080..109764022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542135.3XP_011540437.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X7

    Conserved Domains (3) summary
    cd11764
    Location:400452
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:1120
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    cl15755
    Location:469534
    SAM_superfamily; SAM (Sterile alpha motif )
  2. XM_011542134.3XP_011540436.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X5

    Conserved Domains (3) summary
    cd11764
    Location:430482
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:1120
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    cl15755
    Location:499564
    SAM_superfamily; SAM (Sterile alpha motif )
  3. XM_011542133.2XP_011540435.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X2

    Conserved Domains (3) summary
    cd11764
    Location:463515
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:25154
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    cl15755
    Location:532597
    SAM_superfamily; SAM (Sterile alpha motif )
  4. XM_017002329.2XP_016857818.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X6

  5. XM_017002328.2XP_016857817.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X4

  6. XM_011542132.2XP_011540434.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X1

    Conserved Domains (3) summary
    cd11764
    Location:464516
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:25154
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
    cl15755
    Location:533598
    SAM_superfamily; SAM (Sterile alpha motif )
  7. XM_017002327.2XP_016857816.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X3

RNA

  1. XR_001737406.2 RNA Sequence

  2. XR_001737407.2 RNA Sequence

    Related
    ENST00000472325.5
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