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NKAIN1 sodium/potassium transporting ATPase interacting 1 [ Homo sapiens (human) ]

Gene ID: 79570, updated on 1-Jun-2020

Summary

Official Symbol
NKAIN1provided by HGNC
Official Full Name
sodium/potassium transporting ATPase interacting 1provided by HGNC
Primary source
HGNC:HGNC:25743
See related
Ensembl:ENSG00000084628 MIM:612871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM77C
Summary
NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Expression
Biased expression in adrenal (RPKM 5.0), brain (RPKM 4.0) and 4 other tissues See more
Orthologs

Genomic context

See NKAIN1 in Genome Data Viewer
Location:
1p35.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (31179270..31239887, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (31652592..31712734, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 22 Neighboring gene uncharacterized LOC107984935 Neighboring gene small nuclear ribonucleoprotein U5 subunit 40 Neighboring gene zinc finger CCHC-type containing 17 Neighboring gene fatty acid binding protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
NHGRI GWA Catalog

General gene information

Markers

Homology

Clone Names

  • FLJ12650

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
Names
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1
Na+/K+ transporting ATPase interacting 1
family with sequence similarity 77, member C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024522.3NP_078798.2  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 precursor

    See identical proteins and their annotated locations for NP_078798.2

    Status: VALIDATED

    Source sequence(s)
    AI884789, AK022712, AK298874, AK299507, AL832547, DB499136
    Consensus CDS
    CCDS339.2
    UniProtKB/Swiss-Prot
    Q4KMZ8
    Related
    ENSP00000362841.2, ENST00000373736.7
    Conserved Domains (1) summary
    pfam05640
    Location:10206
    NKAIN; Na,K-Atpase Interacting protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    31179270..31239887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002320.1XP_016857809.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 isoform X1

    Related
    ENSP00000433225.1, ENST00000526106.5
    Conserved Domains (1) summary
    pfam05640
    Location:10179
    NKAIN; Na,K-Atpase Interacting protein
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