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OR4K1 olfactory receptor family 4 subfamily K member 1 [ Homo sapiens (human) ]

Gene ID: 79544, updated on 22-Sep-2022

Summary

Official Symbol
OR4K1provided by HGNC
Official Full Name
olfactory receptor family 4 subfamily K member 1provided by HGNC
Primary source
HGNC:HGNC:14726
See related
Ensembl:ENSG00000155249 AllianceGenome:HGNC:14726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR14-19
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OR4K1 in Genome Data Viewer
Location:
14q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (19920263..19936757)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14130357..14136196)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20399076..20404916)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903278 Neighboring gene ATPase Na+/K+ transporting subunit beta 3 pseudogene Neighboring gene olfactory receptor family 4 subfamily K member 4 pseudogene Neighboring gene olfactory receptor family 4 subfamily K member 5 Neighboring gene olfactory receptor family 4 subfamily K member 16 pseudogene Neighboring gene olfactory receptor family 4 subfamily K member 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
olfactory receptor 4K1
Names
olfactory receptor OR14-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004063.3NP_001004063.2  olfactory receptor 4K1

    See identical proteins and their annotated locations for NP_001004063.2

    Status: VALIDATED

    Source sequence(s)
    AL359218, AL391156
    Consensus CDS
    CCDS32025.1
    UniProtKB/Swiss-Prot
    Q8NGD4, Q96R73
    Related
    ENSP00000493193.1, ENST00000641172.1
    Conserved Domains (2) summary
    pfam00001
    Location:41287
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31301
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    19920263..19936757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537153.3XP_011535455.1  olfactory receptor 4K1 isoform X1

    See identical proteins and their annotated locations for XP_011535455.1

    UniProtKB/Swiss-Prot
    Q8NGD4, Q96R73
    Related
    ENSP00000493205.1, ENST00000641429.1
    Conserved Domains (2) summary
    pfam00001
    Location:41287
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31301
    7tm_4; Olfactory receptor

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791796.1 Reference GRCh38.p14 PATCHES

    Range
    133599..139439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    14130357..14136196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)