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kiaa0319 KIAA0319 [ Danio rerio (zebrafish) ]

Gene ID: 794624, updated on 17-Sep-2024

Summary

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Official Symbol
kiaa0319provided by ZNC
Official Full Name
KIAA0319provided by ZNC
Primary source
ZFIN:ZDB-GENE-100922-40
See related
Ensembl:ENSDARG00000103001 AllianceGenome:ZFIN:ZDB-GENE-100922-40
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:eu253; si:ch73-215d9.1
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including axis; liver; nervous system; notochord; and tail bud. Orthologous to human KIAA0319 (KIAA0319). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 16
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (36906719..36932333)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (36952792..36978594)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene purine nucleoside phosphorylase 4b Neighboring gene tyrosyl-DNA phosphodiesterase 2 Neighboring gene aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration. Gostic M, et al. J Comp Neurol, 2019 Nov 1. PMID 30950042, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration.
    Title: The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dyslexia-associated protein KIAA0319
Names
dyslexia-associated protein KIAA0319-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    36906719..36932333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001334594.9 → XP_001334630.5  dyslexia-associated protein KIAA0319 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IQX4, A0A8M1PRZ2
    Related
    ENSDARP00000137251.1, ENSDART00000169208.2
    Conserved Domains (3) summary
    smart00089
    Location:693 → 781
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
    cd00146
    Location:435 → 495
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...
    cl06508
    Location:45 → 95
    MANEC; MANEC domain

  2. XM_068214200.1 → XP_068070301.1  dyslexia-associated protein KIAA0319 isoform X2

    Related
    ENSDARP00000157137.1, ENSDART00000180470.1

RNA

  1. XR_002455821.2 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394967.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    949..21487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218825.1 → XP_068074926.1  dyslexia-associated protein KIAA0319 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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