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MMP28 matrix metallopeptidase 28 [ Homo sapiens (human) ]

Gene ID: 79148, updated on 1-Aug-2020

Summary

Official Symbol
MMP28provided by HGNC
Official Full Name
matrix metallopeptidase 28provided by HGNC
Primary source
HGNC:HGNC:14366
See related
Ensembl:ENSG00000271447 MIM:608417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MM28; MMP25; MMP-25; MMP-28; EPILYSIN
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Broad expression in fat (RPKM 8.8), skin (RPKM 8.6) and 18 other tissues See more
Orthologs

Genomic context

See MMP28 in Genome Data Viewer
Location:
17q12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (35756249..35795707, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34083316..34122711, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RAS like family 10 member B Neighboring gene growth arrest specific 2 like 2 Neighboring gene uncharacterized LOC107985067 Neighboring gene chromosome 17 open reading frame 50 Neighboring gene TATA-box binding protein associated factor 15 Neighboring gene probable ribosome biogenesis protein RLP24 Neighboring gene HEAT repeat containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of macrophage chemotaxis IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
matrix metalloproteinase-28
Names
matrix metalloprotease MMP25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032278.3NP_001027449.1  matrix metalloproteinase-28 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001027449.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons but includes an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is significantly shorter than isoform 1.
    Source sequence(s)
    AK122604, BC011774, HY027589
    Consensus CDS
    CCDS45651.1
    UniProtKB/Swiss-Prot
    Q9H239
    UniProtKB/TrEMBL
    B3KV06
    Related
    ENSP00000483539.1, ENST00000612672.1
    Conserved Domains (1) summary
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
  2. NM_024302.5NP_077278.1  matrix metalloproteinase-28 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_077278.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1)
    Source sequence(s)
    AA813101, AF330002, AK122604
    Consensus CDS
    CCDS74036.1
    UniProtKB/Swiss-Prot
    Q9H239
    UniProtKB/TrEMBL
    B3KV06
    Related
    ENSP00000473853.1, ENST00000605424.6
    Conserved Domains (4) summary
    cd00094
    Location:321510
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:129284
    Peptidase_M10; Matrixin
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
  3. NM_032950.4NP_116568.1  matrix metalloproteinase-28 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_116568.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon in the 3' region, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA813101, AF330002, AK122604, BC002631
    Consensus CDS
    CCDS76996.1
    UniProtKB/Swiss-Prot
    Q9H239
    UniProtKB/TrEMBL
    B3KV06, C0H5X0
    Related
    ENSP00000483299.1, ENST00000615136.4
    Conserved Domains (3) summary
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
    cl02471
    Location:321389
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RNA

  1. NR_111988.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon and contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC015849, AK122604, BM702847
    Related
    ENST00000619655.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    35756249..35795707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025064.1XP_016880553.1  matrix metalloproteinase-28 isoform X7

  2. XM_011525231.1XP_011523533.1  matrix metalloproteinase-28 isoform X6

    Conserved Domains (4) summary
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:129284
    Peptidase_M10; Matrixin
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
    cl02471
    Location:321389
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  3. XM_011525225.1XP_011523527.1  matrix metalloproteinase-28 isoform X2

    See identical proteins and their annotated locations for XP_011523527.1

    Conserved Domains (4) summary
    cd00094
    Location:246435
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:122209
    Peptidase_M10; Matrixin
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
    cl00064
    Location:126209
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  4. XM_011525232.2XP_011523534.2  matrix metalloproteinase-28 isoform X1

  5. XM_017025062.1XP_016880551.1  matrix metalloproteinase-28 isoform X7

  6. XM_011525230.1XP_011523532.1  matrix metalloproteinase-28 isoform X4

    Conserved Domains (4) summary
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:129284
    Peptidase_M10; Matrixin
    pfam01471
    Location:3186
    PG_binding_1; Putative peptidoglycan binding domain
    cl02471
    Location:321409
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  7. XM_011525226.2XP_011523528.1  matrix metalloproteinase-28 isoform X3

    See identical proteins and their annotated locations for XP_011523528.1

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  8. XM_011525228.1XP_011523530.1  matrix metalloproteinase-28 isoform X3

    See identical proteins and their annotated locations for XP_011523530.1

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  9. XM_017025061.1XP_016880550.1  matrix metalloproteinase-28 isoform X5

  10. XM_011525229.2XP_011523531.1  matrix metalloproteinase-28 isoform X3

    See identical proteins and their annotated locations for XP_011523531.1

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  11. XM_011525227.1XP_011523529.1  matrix metalloproteinase-28 isoform X3

    See identical proteins and their annotated locations for XP_011523529.1

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  12. XM_024450943.1XP_024306711.1  matrix metalloproteinase-28 isoform X3

    Conserved Domains (2) summary
    cd00094
    Location:236425
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:44199
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  13. XM_017025063.1XP_016880552.1  matrix metalloproteinase-28 isoform X7

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    397..30173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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