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METTL22 methyltransferase like 22 [ Homo sapiens (human) ]

Gene ID: 79091, updated on 1-Jun-2020

Summary

Official Symbol
METTL22provided by HGNC
Official Full Name
methyltransferase like 22provided by HGNC
Primary source
HGNC:HGNC:28368
See related
Ensembl:ENSG00000067365 MIM:615261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C16orf68
Summary
This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in testis (RPKM 2.7), endometrium (RPKM 1.3) and 25 other tissues See more
Orthologs

Genomic context

See METTL22 in Genome Data Viewer
Location:
16p13.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (8621670..8673565)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (8715497..8740079)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S14 pseudogene Neighboring gene transmembrane protein 114 Neighboring gene RNA, 7SL, cytoplasmic 743, pseudogene Neighboring gene 4-aminobutyrate aminotransferase Neighboring gene RNA, U7 small nuclear 63 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2654, FLJ12433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
peptidyl-lysine methylation IEA
Inferred from Electronic Annotation
more info
 
protein methylation IDA
Inferred from Direct Assay
more info
PubMed 
protein methylation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
methyltransferase-like protein 22
Names
LP8272

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024109.4NP_077014.4  methyltransferase-like protein 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AC007224, AC138420
    Consensus CDS
    CCDS10533.2
    Related
    ENSP00000371345.3, ENST00000381920.8

RNA

  1. NR_134608.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant (2) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007224, AC138420

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    8621670..8673565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023661.2XP_016879150.1  methyltransferase-like protein 22 isoform X3

  2. XM_024450440.1XP_024306208.1  methyltransferase-like protein 22 isoform X7

  3. XM_017023659.2XP_016879148.1  methyltransferase-like protein 22 isoform X1

  4. XM_017023662.2XP_016879151.1  methyltransferase-like protein 22 isoform X8

  5. XM_011522657.3XP_011520959.1  methyltransferase-like protein 22 isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:164337
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. XM_005255571.3XP_005255628.1  methyltransferase-like protein 22 isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:164338
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. XM_005255570.4XP_005255627.1  methyltransferase-like protein 22 isoform X4

    Conserved Domains (1) summary
    cl17173
    Location:164337
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  8. XM_024450439.1XP_024306207.1  methyltransferase-like protein 22 isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:164320
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  9. XM_017023660.1XP_016879149.1  methyltransferase-like protein 22 isoform X1

RNA

  1. XR_001751981.2 RNA Sequence

  2. XR_932926.3 RNA Sequence

  3. XR_001751985.2 RNA Sequence

  4. XR_932928.3 RNA Sequence

  5. XR_243305.3 RNA Sequence

  6. XR_001751984.2 RNA Sequence

  7. XR_002957841.1 RNA Sequence

  8. XR_001751983.2 RNA Sequence

    Related
    ENST00000163678.11
  9. XR_001751982.2 RNA Sequence

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