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NABP2 nucleic acid binding protein 2 [ Homo sapiens (human) ]

Gene ID: 79035, updated on 8-Jul-2021

Summary

Official Symbol
NABP2provided by HGNC
Official Full Name
nucleic acid binding protein 2provided by HGNC
Primary source
HGNC:HGNC:28412
See related
Ensembl:ENSG00000139579 MIM:612104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSB1; hSSB1; OBFC2B; SOSS-B1
Summary
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Expression
Ubiquitous expression in brain (RPKM 8.5), adrenal (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

See NABP2 in Genome Data Viewer
Location:
12q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56222012..56229858)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56618126..56623638)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984468 Neighboring gene ring finger protein 41 Neighboring gene solute carrier family 39 member 5 Neighboring gene ankyrin repeat domain 52 Neighboring gene coenzyme Q10A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2731

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables C-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables G-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SOSS complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SOSS complex subunit B1
Names
LP3587
oligonucleotide/oligosaccharide-binding fold containing 2B
oligonucleotide/oligosaccharide-binding fold-containing protein 2B
sensor of single-strand DNA complex subunit B1
sensor of ssDNA subunit B1
single strand DNA-binding protein 1
single-stranded DNA-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024068.4NP_076973.1  SOSS complex subunit B1

    See identical proteins and their annotated locations for NP_076973.1

    Status: VALIDATED

    Source sequence(s)
    AI038029, BC006171, BG697807
    Consensus CDS
    CCDS8911.1
    UniProtKB/Swiss-Prot
    Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89
    Related
    ENSP00000267023.4, ENST00000267023.9
    Conserved Domains (2) summary
    PRK14971
    Location:106153
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:1895
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56222012..56229858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449184.1XP_024304952.1  SOSS complex subunit B1 isoform X3

    Conserved Domains (2) summary
    PRK14971
    Location:106153
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:1895
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
  2. XM_005269149.5XP_005269206.1  SOSS complex subunit B1 isoform X3

    See identical proteins and their annotated locations for XP_005269206.1

    UniProtKB/Swiss-Prot
    Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89
    Conserved Domains (2) summary
    PRK14971
    Location:106153
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:1895
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
  3. XM_005269147.3XP_005269204.1  SOSS complex subunit B1 isoform X2

    See identical proteins and their annotated locations for XP_005269204.1

    Conserved Domains (1) summary
    cd04491
    Location:34111
    SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...
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