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NABP2 nucleic acid binding protein 2 [ Homo sapiens (human) ]

Gene ID: 79035, updated on 7-Sep-2023

Summary

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Official Symbol
NABP2provided by HGNC
Official Full Name
nucleic acid binding protein 2provided by HGNC
Primary source
HGNC:HGNC:28412
See related
Ensembl:ENSG00000139579 MIM:612104; AllianceGenome:HGNC:28412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSB1; hSSB1; OBFC2B; SOSS-B1
Summary
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Expression
Ubiquitous expression in brain (RPKM 8.5), adrenal (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

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See NABP2 in Genome Data Viewer
Location:
12q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56222015..56229854)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56189608..56197479)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56618126..56623638)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984468 Neighboring gene ring finger protein 41 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56615664-56616598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56616599-56617532 Neighboring gene solute carrier family 39 member 5 Neighboring gene ankyrin repeat domain 52 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56650178-56651170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56660797-56661296 Neighboring gene coenzyme Q10A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer. Adams MN, et al. Prostate, 2023 May. PMID 36811381
  2. A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution. Touma C, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27387285, Free PMC Article
  3. hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress. Paquet N, et al. Sci Rep, 2016 Jun 8. PMID 27273218, Free PMC Article
  4. Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Bolderson E, et al. Nucleic Acids Res, 2014 Jun. PMID 24753408, Free PMC Article
  5. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. Yang SH, et al. EMBO J, 2013 Jan 9. PMID 23178594, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer.
    Title: hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer.
  2. Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.
    Title: Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.
  3. findings demonstrate a novel hSSB1 regulatory mechanism for the repair of damaged DNA
    Title: hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.
  4. Our data highlights that BLM helicase and hSSB1 function in a dynamic complex in cells and that this complex is likely required for BLM protein stability and function.
    Title: hSSB1 associates with and promotes stability of the BLM helicase.
  5. the detailed molecular mechanism in solution of ssDNA binding by hSSB1, a major player in the maintenance of genomic stability, is reported.
    Title: A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution.
  6. In the absence of hSSB1, human 8-oxoguanine glycosylase 1 does not localize to chromatin, resulting in the accumulation of 8-oxoguanine in the genome.
    Title: hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.
  7. The findings demonstrate the importance of hSSB1 in maintaining and repairing DNA replication forks and for overall genomic stability.
    Title: Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.
  8. Identification of EEf1E1 and OBFC2B as novel BRCA1-partner genes in the DNA double-strand break repair pathway.
    Title: Identification of two novel BRCA1-partner genes in the DNA double-strand break repair pathway.
  9. SOSS complexes, containing SSB1, do not localize with Replication Protein A (RPA) to replication sites in human cells, yet have a strong effect on double-strand break resection and homologous recombination.
    Title: The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.
  10. hSSB1 and hSSB2 form two separate complexes with similar structures, and both complexes participate in DNA damage response.
    Title: HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2731

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables C-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables DNA polymerase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables G-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization to telomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2/M transition checkpoint IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic G2/M transition checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of SOSS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SOSS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SOSS complex subunit B1
Names
LP3587
oligonucleotide/oligosaccharide-binding fold containing 2B
oligonucleotide/oligosaccharide-binding fold-containing protein 2B
sensor of single-strand DNA complex subunit B1
sensor of ssDNA subunit B1
single strand DNA-binding protein 1
single-stranded DNA-binding protein 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024068.4 → NP_076973.1  SOSS complex subunit B1

    See identical proteins and their annotated locations for NP_076973.1

    Status: VALIDATED

    Source sequence(s)
    AI038029, BC006171, BG697807
    Consensus CDS
    CCDS8911.1
    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89
    Related
    ENSP00000267023.4, ENST00000267023.9
    Conserved Domains (2) summary
    PRK14971
    Location:106 → 153
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:18 → 95
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56222015..56229854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429533.1 → XP_047285489.1  SOSS complex subunit B1 isoform X3

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89

  2. XM_005269149.6 → XP_005269206.1  SOSS complex subunit B1 isoform X3

    See identical proteins and their annotated locations for XP_005269206.1

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89
    Conserved Domains (2) summary
    PRK14971
    Location:106 → 153
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:18 → 95
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

  3. XM_047429532.1 → XP_047285488.1  SOSS complex subunit B1 isoform X3

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89

  4. XM_005269147.4 → XP_005269204.1  SOSS complex subunit B1 isoform X2

    See identical proteins and their annotated locations for XP_005269204.1

    Conserved Domains (1) summary
    cd04491
    Location:34 → 111
    SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...

  5. XM_047429531.1 → XP_047285487.1  SOSS complex subunit B1 isoform X1

    Related
    ENSP00000369545.2, ENST00000380198.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56189608..56197479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373200.1 → XP_054229175.1  SOSS complex subunit B1 isoform X3

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89

  2. XM_054373201.1 → XP_054229176.1  SOSS complex subunit B1 isoform X3

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89

  3. XM_054373199.1 → XP_054229174.1  SOSS complex subunit B1 isoform X2

  4. XM_054373198.1 → XP_054229173.1  SOSS complex subunit B1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BQ15.1 GenPept UniProtKB/Swiss-Prot:Q9BQ15

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