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NABP2 nucleic acid binding protein 2 [ Homo sapiens (human) ]

Gene ID: 79035, updated on 11-Jun-2025
Official Symbol
NABP2provided by HGNC
Official Full Name
nucleic acid binding protein 2provided by HGNC
Primary source
HGNC:HGNC:28412
See related
Ensembl:ENSG00000139579 MIM:612104; AllianceGenome:HGNC:28412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSB1; hSSB1; OBFC2B; SOSS-B1
Summary
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Expression
Ubiquitous expression in brain (RPKM 8.5), adrenal (RPKM 8.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See NABP2 in Genome Data Viewer
Location:
12q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56222015..56229854)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56189608..56197479)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56618126..56623638)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4550 Neighboring gene ring finger protein 41 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6481 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56615664-56616598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56616599-56617532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4551 Neighboring gene solute carrier family 39 member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:56630689-56630907 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29670 Neighboring gene ankyrin repeat domain 52 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29671 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56650178-56651170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4554 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29674 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29675 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6485 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56660797-56661296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6486 Neighboring gene coenzyme Q10A

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC2731

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables C-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables G-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization to telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2/M transition checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic G2/M transition checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic G2/M transition checkpoint IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic G2/M transition checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere capping IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SOSS complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SOSS complex IEA
Inferred from Electronic Annotation
more info
 
part_of SOSS complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
SOSS complex subunit B1
Names
LP3587
oligonucleotide/oligosaccharide-binding fold containing 2B
oligonucleotide/oligosaccharide-binding fold-containing protein 2B
sensor of single-strand DNA complex subunit B1
sensor of ssDNA subunit B1
single strand DNA-binding protein 1
single-stranded DNA-binding protein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024068.4NP_076973.1  SOSS complex subunit B1

    See identical proteins and their annotated locations for NP_076973.1

    Status: VALIDATED

    Source sequence(s)
    AI038029, BC006171, BG697807
    Consensus CDS
    CCDS8911.1
    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
    Related
    ENSP00000267023.4, ENST00000267023.9
    Conserved Domains (2) summary
    PRK14971
    Location:106153
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:1895
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56222015..56229854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429533.1XP_047285489.1  SOSS complex subunit B1 isoform X3

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
  2. XM_005269149.6XP_005269206.1  SOSS complex subunit B1 isoform X3

    See identical proteins and their annotated locations for XP_005269206.1

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
    Conserved Domains (2) summary
    PRK14971
    Location:106153
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:1895
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
  3. XM_047429532.1XP_047285488.1  SOSS complex subunit B1 isoform X3

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
  4. XM_005269147.4XP_005269204.1  SOSS complex subunit B1 isoform X2

    See identical proteins and their annotated locations for XP_005269204.1

    Conserved Domains (1) summary
    cd04491
    Location:34111
    SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...
  5. XM_047429531.1XP_047285487.1  SOSS complex subunit B1 isoform X1

    Related
    ENSP00000369545.2, ENST00000380198.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56189608..56197479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373200.1XP_054229175.1  SOSS complex subunit B1 isoform X3

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
  2. XM_054373201.1XP_054229176.1  SOSS complex subunit B1 isoform X3

    UniProtKB/Swiss-Prot
    A6NDF8, Q6XYC8, Q9BQ15
  3. XM_054373199.1XP_054229174.1  SOSS complex subunit B1 isoform X2

  4. XM_054373198.1XP_054229173.1  SOSS complex subunit B1 isoform X1