Format

Send to:

Choose Destination

NABP2 nucleic acid binding protein 2 [ Homo sapiens (human) ]

Gene ID: 79035, updated on 13-Mar-2020

Summary

Official Symbol
NABP2provided by HGNC
Official Full Name
nucleic acid binding protein 2provided by HGNC
Primary source
HGNC:HGNC:28412
See related
Ensembl:ENSG00000139579 MIM:612104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSB1; hSSB1; OBFC2B; SOSS-B1
Summary
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Expression
Ubiquitous expression in brain (RPKM 8.5), adrenal (RPKM 8.0) and 25 other tissues See more
Orthologs

Genomic context

See NABP2 in Genome Data Viewer
Location:
12q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56222012..56229858)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56615813..56623638)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984468 Neighboring gene ring finger protein 41 Neighboring gene solute carrier family 39 member 5 Neighboring gene ankyrin repeat domain 52 Neighboring gene coenzyme Q10A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2731

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT C-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
G-rich strand telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization to telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SOSS complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SOSS complex subunit B1
Names
LP3587
oligonucleotide/oligosaccharide-binding fold containing 2B
oligonucleotide/oligosaccharide-binding fold-containing protein 2B
sensor of single-strand DNA complex subunit B1
sensor of ssDNA subunit B1
single strand DNA-binding protein 1
single-stranded DNA-binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024068.4NP_076973.1  SOSS complex subunit B1

    See identical proteins and their annotated locations for NP_076973.1

    Status: VALIDATED

    Source sequence(s)
    AI038029, BC006171, BG697807
    Consensus CDS
    CCDS8911.1
    UniProtKB/Swiss-Prot
    Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89
    Related
    ENSP00000267023.4, ENST00000267023.9
    Conserved Domains (2) summary
    cd04491
    Location:1895
    SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...
    cl26247
    Location:106153
    DNA_pol3_delta2; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56222012..56229858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449184.1XP_024304952.1  SOSS complex subunit B1 isoform X3

    Conserved Domains (2) summary
    cd04491
    Location:1895
    SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...
    cl26247
    Location:106153
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  2. XM_005269149.5XP_005269206.1  SOSS complex subunit B1 isoform X3

    See identical proteins and their annotated locations for XP_005269206.1

    UniProtKB/Swiss-Prot
    Q9BQ15
    UniProtKB/TrEMBL
    A0A024RB89
    Conserved Domains (2) summary
    cd04491
    Location:1895
    SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...
    cl26247
    Location:106153
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  3. XM_005269147.3XP_005269204.1  SOSS complex subunit B1 isoform X2

    See identical proteins and their annotated locations for XP_005269204.1

    Conserved Domains (1) summary
    cd04491
    Location:34111
    SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...
Support Center