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INTS15 integrator complex subunit 15 [ Homo sapiens (human) ]

Gene ID: 79034, updated on 5-Aug-2022

Summary

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Official Symbol
INTS15provided by HGNC
Official Full Name
integrator complex subunit 15provided by HGNC
Primary source
HGNC:HGNC:21702
See related
Ensembl:ENSG00000146576 AllianceGenome:HGNC:21702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7orf26
Expression
Ubiquitous expression in testis (RPKM 9.0), spleen (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

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See INTS15 in Genome Data Viewer
Location:
7p22.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6590021..6608726)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6709194..6727910)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6629652..6648357)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927325 Neighboring gene Grid2 interacting protein Neighboring gene uncharacterized LOC124901582 Neighboring gene zinc finger DHHC-type palmitoyltransferase 4 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene zinc finger protein 853 Neighboring gene Sharpr-MPRA regulatory region 15225 Neighboring gene zinc finger protein 316

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies. Drew K, et al. Mol Syst Biol, 2021 May. PMID 33973408, Free PMC Article
  2. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Malovannaya A, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133760, Free PMC Article
  3. CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1. Luo H, et al. Cell Death Dis, 2021 Aug 30. PMID 34462429, Free PMC Article
  4. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836
  5. The cell proliferation antigen Ki-67 organises heterochromatin. Sobecki M, et al. Elife, 2016 Mar 7. PMID 26949251, Free PMC Article

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2718

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
integrator complex subunit 15; uncharacterized protein C7orf26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303039.2 → NP_001289968.1  integrator complex subunit 15 isoform 2

    See identical proteins and their annotated locations for NP_001289968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame segment in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC001076, BI599533, BM977018, CA454040
    Consensus CDS
    CCDS78206.1
    UniProtKB/Swiss-Prot
    Q96N11
    Related
    ENSP00000351974.5, ENST00000359073.9
    Conserved Domains (1) summary
    pfam14964
    Location:2 → 284
    DUF4507; Domain of unknown function (DUF4507)

  2. NM_024067.4 → NP_076972.2  integrator complex subunit 15 isoform 1

    See identical proteins and their annotated locations for NP_076972.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK056149, BI599533, BM977018, CA454040
    Consensus CDS
    CCDS5353.1
    UniProtKB/Swiss-Prot
    Q96N11, Q9BQ43
    Related
    ENSP00000340220.5, ENST00000344417.10
    Conserved Domains (1) summary
    pfam14964
    Location:2 → 381
    DUF4507; Domain of unknown function (DUF4507)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6590021..6608726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515518.4 → XP_011513820.2  uncharacterized protein C7orf26 isoform X2

  2. XM_005249845.6 → XP_005249902.1  uncharacterized protein C7orf26 isoform X1

    Conserved Domains (1) summary
    pfam14964
    Location:2 → 381
    DUF4507; Domain of unknown function (DUF4507)

  3. XM_047420833.1 → XP_047276789.1  uncharacterized protein C7orf26 isoform X4

  4. XM_017012614.3 → XP_016868103.1  uncharacterized protein C7orf26 isoform X3

RNA

  1. XR_926946.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6709194..6727910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96N11.1 GenPept UniProtKB/Swiss-Prot:Q96N11

Gene LinkOut

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