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TRIR telomerase RNA component interacting RNase [ Homo sapiens (human) ]

Gene ID: 79002, updated on 23-Nov-2021

Summary

Official Symbol
TRIRprovided by HGNC
Official Full Name
telomerase RNA component interacting RNaseprovided by HGNC
Primary source
HGNC:HGNC:28424
See related
Ensembl:ENSG00000123144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TERCIR; fSAP18; C19orf43
Expression
Ubiquitous expression in fat (RPKM 63.1), colon (RPKM 57.1) and 25 other tissues See more
Orthologs
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Genomic context

See TRIR in Genome Data Viewer
Location:
19p13.13
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12730640..12734684, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12841454..12845498, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transportin 2 Neighboring gene small nucleolar RNA, C/D box 135 Neighboring gene small nucleolar RNA, C/D box 41 Neighboring gene CRISPRi-FlowFISH-validated RAD23A regulatory element Neighboring gene CRISPRi-FlowFISH-validated TRIR regulatory element Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene bestrophin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2803

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3'-5' exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-3' exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
telomerase RNA component interacting RNase
Names
My029 protein
exoribonuclease TRIR
uncharacterized protein C19orf43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329738.2NP_001316667.1  telomerase RNA component interacting RNase isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC000216, BQ668685, BU599327
    Consensus CDS
    CCDS86709.1
    UniProtKB/Swiss-Prot
    Q9BQ61
    UniProtKB/TrEMBL
    K7EN60
    Related
    ENSP00000466801.1, ENST00000592273.5
  2. NM_001329739.2NP_001316668.1  telomerase RNA component interacting RNase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded protein (isoform 3) has a distinct, shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC018761
    Consensus CDS
    CCDS86710.1
    UniProtKB/TrEMBL
    K7ELS0
    Related
    ENSP00000466196.1, ENST00000588213.1
  3. NM_024038.4NP_076943.1  telomerase RNA component interacting RNase isoform 1

    See identical proteins and their annotated locations for NP_076943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (1).
    Source sequence(s)
    BC000216
    Consensus CDS
    CCDS12279.1
    UniProtKB/Swiss-Prot
    Q9BQ61
    Related
    ENSP00000242784.3, ENST00000242784.5

RNA

  1. NR_138095.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC000216, BM554534, BQ668685
    Related
    ENST00000591254.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    12730640..12734684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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