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AUNIP aurora kinase A and ninein interacting protein [ Homo sapiens (human) ]

Gene ID: 79000, updated on 2-Nov-2024

Summary

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Official Symbol
AUNIPprovided by HGNC
Official Full Name
aurora kinase A and ninein interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:28363
See related
Ensembl:ENSG00000127423 MIM:620397; AllianceGenome:HGNC:28363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIBP; C1orf135
Summary
Enables damaged DNA binding activity. Involved in double-strand break repair via homologous recombination; negative regulation of double-strand break repair via nonhomologous end joining; and spindle organization. Located in centrosome; site of DNA damage; and spindle pole. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 11.8), adrenal (RPKM 7.3) and 24 other tissues See more
Orthologs
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Genomic context

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See AUNIP in Genome Data Viewer
Location:
1p36.11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25831906..25859457, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25669339..25696890, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26158397..26185948, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene selenoprotein N Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26137118-26137992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26144488-26144988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 467 Neighboring gene uncharacterized LOC646471 Neighboring gene mitochondrial fission regulator 1 like Neighboring gene hESC enhancers GRCh37_chr1:26185603-26186228 and GRCh37_chr1:26186229-26186854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26189139-26189908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26196207-26196708 Neighboring gene progestin and adipoQ receptor family member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26201379-26201878 Neighboring gene stathmin 1 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma. Yang Z, et al. EBioMedicine, 2019 Sep. PMID 31409573, Free PMC Article
  2. AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway. Lou J, et al. Nat Commun, 2017 Oct 17. PMID 29042561, Free PMC Article
  3. Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. Lieu AS, et al. Int J Oncol, 2010 Aug. PMID 20596670
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
  5. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2603, FLJ14264

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aurora kinase A- and ninein-interacting protein
Names
aurora A-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287490.2 → NP_001274419.1  aurora kinase A- and ninein-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_001274419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL020996, BF987554, BJ989876, GQ844687
    Consensus CDS
    CCDS72731.1
    UniProtKB/Swiss-Prot
    Q9H7T9
    Related
    ENSP00000443647.1, ENST00000538789.5
    Conserved Domains (1) summary
    pfam15334
    Location:26 → 348
    AIB; Aurora kinase A and ninein interacting protein

  2. NM_024037.3 → NP_076942.1  aurora kinase A- and ninein-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_076942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI198661, AL020996, BC000209, BJ989876
    Consensus CDS
    CCDS266.1
    UniProtKB/Swiss-Prot
    C9EI59, Q53F70, Q9H7T9
    Related
    ENSP00000363416.4, ENST00000374298.4
    Conserved Domains (1) summary
    pfam15334
    Location:26 → 350
    AIB; Aurora kinase A and ninein interacting protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    25831906..25859457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430116.1 → XP_047286072.1  aurora kinase A- and ninein-interacting protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    25669339..25696890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338672.1 → XP_054194647.1  aurora kinase A- and ninein-interacting protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H7T9.1 GenPept UniProtKB/Swiss-Prot:Q9H7T9

Gene LinkOut

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