Format

Send to:

Choose Destination

PRR14 proline rich 14 [ Homo sapiens (human) ]

Gene ID: 78994, updated on 2-Aug-2021

Summary

Official Symbol
PRR14provided by HGNC
Official Full Name
proline rich 14provided by HGNC
Primary source
HGNC:HGNC:28458
See related
Ensembl:ENSG00000156858 MIM:617423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in spleen (RPKM 13.5), bone marrow (RPKM 12.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PRR14 in Genome Data Viewer
Location:
16p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30650778..30656413)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30662099..30667734)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 785 Neighboring gene zinc finger protein 689 Neighboring gene fibrosin Neighboring gene RNA, U6 small nuclear 416, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3121, DKFZp781A13198

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear lamina IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320464.3NP_001307393.1  proline-rich protein 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL599080, BC050677
    Consensus CDS
    CCDS10687.1
    UniProtKB/Swiss-Prot
    Q9BWN1
    UniProtKB/TrEMBL
    A0A024QZB5
    Related
    ENSP00000441641.2, ENST00000542965.2
    Conserved Domains (2) summary
    pfam15386
    Location:463512
    Tantalus; Drosophila Tantalus-like
    cl26464
    Location:2353
    Atrophin-1; Atrophin-1 family
  2. NM_024031.5NP_076936.1  proline-rich protein 14

    See identical proteins and their annotated locations for NP_076936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC050677
    Consensus CDS
    CCDS10687.1
    UniProtKB/Swiss-Prot
    Q9BWN1
    UniProtKB/TrEMBL
    A0A024QZB5
    Related
    ENSP00000300835.4, ENST00000300835.9
    Conserved Domains (2) summary
    pfam15386
    Location:463512
    Tantalus; Drosophila Tantalus-like
    cl26464
    Location:2353
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30650778..30656413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center