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MRPL57 mitochondrial ribosomal protein L57 [ Homo sapiens (human) ]

Gene ID: 78988, updated on 21-Dec-2019

Summary

Official Symbol
MRPL57provided by HGNC
Official Full Name
mitochondrial ribosomal protein L57provided by HGNC
Primary source
HGNC:HGNC:14514
See related
Ensembl:ENSG00000173141 MIM:611997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRP63; bMRP63
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 7.1), prostate (RPKM 6.2) and 25 other tissues See more
Orthologs

Genomic context

See MRPL57 in Genome Data Viewer
Location:
13q12.11
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (21176649..21179084)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21750372..21753223)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene Sin3A associated protein 18 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene long intergenic non-protein coding RNA 1046 Neighboring gene uncharacterized LOC105370105 Neighboring gene estrogen-related receptor alpha pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3243

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosomal protein 63, mitochondrial
Names
hMRP63
mitochondrial large ribosomal subunit protein mL63
mitochondrial ribosomal protein 63
mitochondrial ribosomal protein bMRP63

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024026.5NP_076931.1  ribosomal protein 63, mitochondrial

    See identical proteins and their annotated locations for NP_076931.1

    Status: REVIEWED

    Source sequence(s)
    AL158032
    Consensus CDS
    CCDS9296.1
    UniProtKB/Swiss-Prot
    Q9BQC6
    UniProtKB/TrEMBL
    A0A024RDM4
    Related
    ENSP00000310726.4, ENST00000309594.5
    Conserved Domains (1) summary
    pfam14978
    Location:14101
    MRP-63; Mitochondrial ribosome protein 63

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    21176649..21179084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020740.2XP_016876229.1  ribosomal protein 63, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9BQC6
    UniProtKB/TrEMBL
    A0A024RDM4
    Conserved Domains (1) summary
    pfam14978
    Location:14101
    MRP-63; Mitochondrial ribosome protein 63
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