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DUSP26 dual specificity phosphatase 26 [ Homo sapiens (human) ]

Gene ID: 78986, updated on 2-Nov-2024

Summary

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Official Symbol
DUSP26provided by HGNC
Official Full Name
dual specificity phosphatase 26provided by HGNC
Primary source
HGNC:HGNC:28161
See related
Ensembl:ENSG00000133878 MIM:618368; AllianceGenome:HGNC:28161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDP4; MKP8; NEAP; DSP-4; LDP-4; MKP-8; NATA1; SKRP3; DUSP24
Summary
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Biased expression in heart (RPKM 15.4), brain (RPKM 12.7) and 8 other tissues See more
Orthologs
mouse all
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Genomic context

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See DUSP26 in Genome Data Viewer
Location:
8p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (33591330..33600023, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (33862584..33871277, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (33448848..33457541, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27222 Neighboring gene ring finger protein 122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19103 Neighboring gene RNA, 7SL, cytoplasmic 621, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:33455207-33455707 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:33483387-33484244 Neighboring gene BUD31 homolog pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:33515643-33516297 Neighboring gene RNA, 7SL, cytoplasmic 457, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor β1(TGFβ1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells. Guler S, et al. Mol Biol Rep, 2022 Nov. PMID 36053282
  2. Falnidamol and cisplatin combinational treatment inhibits non-small cell lung cancer (NSCLC) by targeting DUSP26-mediated signal pathways. Cui Z, et al. Free Radic Biol Med, 2022 Apr. PMID 35278641
  3. A Review of DUSP26: Structure, Regulation and Relevance in Human Disease. Thompson EM, et al. Int J Mol Sci, 2021 Jan 14. PMID 33466673, Free PMC Article
  4. Biochemical and biological characterization of a neuroendocrine-associated phosphatase. Wang JY, et al. J Neurochem, 2006 Jul. PMID 16805799
  5. Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. Takagaki K, et al. Mol Cell Biochem, 2007 Feb. PMID 17001450

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor beta1(TGFbeta1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells.
    Title: Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor β1(TGFβ1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells.
  2. Falnidamol and cisplatin combinational treatment inhibits non-small cell lung cancer (NSCLC) by targeting DUSP26-mediated signal pathways.
    Title: Falnidamol and cisplatin combinational treatment inhibits non-small cell lung cancer (NSCLC) by targeting DUSP26-mediated signal pathways.
  3. Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death.
    Title: Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death.
  4. DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells.
    Title: DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells.
  5. A Review of DUSP26: Structure, Regulation and Relevance in Human Disease.
    Title: A Review of DUSP26: Structure, Regulation and Relevance in Human Disease.
  6. DUSP26 might be a promising therapeutic target for developing effective treatments against Diabetic nephropathy progression.
    Title: DUSP26 regulates podocyte oxidative stress and fibrosis in a mouse model with diabetic nephropathy through the mediation of ROS.
  7. overexpression in liver cell line attenuated lipid deposition and inflammation induced by palmitate
    Title: Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression.
  8. Enhanced expression of DUSP26 was observed in the hippocampus of Alzheimer's disease patients.
    Title: Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia.
  9. results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth.
    Title: The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth.
  10. The study reports the 1.68 A crystal structure of a catalytically inactive mutant (Cys152Ser) of DUSP26 lacking the first 60 N-terminal residues (DeltaN60-C/S-DUSP26).
    Title: Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC1136, MGC2627

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity protein phosphatase 26
Names
MAP kinase phosphatase 8
Novel amplified gene in thyroid anaplastic cancer
dual specificity phosphatase 26 (putative)
dual specificity phosphatase SKRP3
low-molecular-mass dual-specificity phosphatase 4
mitogen-activated protein kinase phosphatase 8
neuroendocrine-associated phosphatase
NP_001292044.1
NP_001292045.1
NP_076930.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305115.2 → NP_001292044.1  dual specificity protein phosphatase 26

    See identical proteins and their annotated locations for NP_001292044.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB237597, AK055704, DA132743
    Consensus CDS
    CCDS6092.1
    UniProtKB/Swiss-Prot
    D3DSV8, Q9BTW0, Q9BV47
    Conserved Domains (1) summary
    cd14578
    Location:62 → 205
    DUSP26; dual specificity protein phosphatase 26

  2. NM_001305116.2 → NP_001292045.1  dual specificity protein phosphatase 26

    See identical proteins and their annotated locations for NP_001292045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB237597, BC001613, BI753746, BI834891, BP196801
    Consensus CDS
    CCDS6092.1
    UniProtKB/Swiss-Prot
    D3DSV8, Q9BTW0, Q9BV47
    Conserved Domains (1) summary
    cd14578
    Location:62 → 205
    DUSP26; dual specificity protein phosphatase 26

  3. NM_024025.3 → NP_076930.1  dual specificity protein phosphatase 26

    See identical proteins and their annotated locations for NP_076930.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB237597, BC001613, DA132743
    Consensus CDS
    CCDS6092.1
    UniProtKB/Swiss-Prot
    D3DSV8, Q9BTW0, Q9BV47
    Related
    ENSP00000256261.4, ENST00000256261.9
    Conserved Domains (1) summary
    cd14578
    Location:62 → 205
    DUSP26; dual specificity protein phosphatase 26

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    33591330..33600023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    33862584..33871277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BV47.1 GenPept UniProtKB/Swiss-Prot:Q9BV47

Gene LinkOut

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