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DUSP26 dual specificity phosphatase 26 [ Homo sapiens (human) ]

Gene ID: 78986, updated on 12-Sep-2021

Summary

Official Symbol
DUSP26provided by HGNC
Official Full Name
dual specificity phosphatase 26provided by HGNC
Primary source
HGNC:HGNC:28161
See related
Ensembl:ENSG00000133878 MIM:618368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDP4; MKP8; NEAP; DSP-4; LDP-4; MKP-8; NATA1; SKRP3; DUSP24
Summary
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Biased expression in heart (RPKM 15.4), brain (RPKM 12.7) and 8 other tissues See more
Orthologs
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Genomic context

See DUSP26 in Genome Data Viewer
Location:
8p12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (33591330..33600023, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (33448848..33457541, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 122 Neighboring gene RNA, 7SL, cytoplasmic 621, pseudogene Neighboring gene uncharacterized LOC105379363 Neighboring gene BUD31 homolog pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1136, MGC2627

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 26
Names
MAP kinase phosphatase 8
Novel amplified gene in thyroid anaplastic cancer
dual specificity phosphatase 26 (putative)
dual specificity phosphatase SKRP3
low-molecular-mass dual-specificity phosphatase 4
mitogen-activated protein kinase phosphatase 8
neuroendocrine-associated phosphatase
NP_001292044.1
NP_001292045.1
NP_076930.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305115.2NP_001292044.1  dual specificity protein phosphatase 26

    See identical proteins and their annotated locations for NP_001292044.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB237597, AK055704, DA132743
    Consensus CDS
    CCDS6092.1
    UniProtKB/Swiss-Prot
    Q9BV47
    Conserved Domains (1) summary
    cd14578
    Location:62205
    DUSP26; dual specificity protein phosphatase 26
  2. NM_001305116.2NP_001292045.1  dual specificity protein phosphatase 26

    See identical proteins and their annotated locations for NP_001292045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB237597, BC001613, BI753746, BI834891, BP196801
    Consensus CDS
    CCDS6092.1
    UniProtKB/Swiss-Prot
    Q9BV47
    Conserved Domains (1) summary
    cd14578
    Location:62205
    DUSP26; dual specificity protein phosphatase 26
  3. NM_024025.3NP_076930.1  dual specificity protein phosphatase 26

    See identical proteins and their annotated locations for NP_076930.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB237597, BC001613, DA132743
    Consensus CDS
    CCDS6092.1
    UniProtKB/Swiss-Prot
    Q9BV47
    Related
    ENSP00000256261.4, ENST00000256261.9
    Conserved Domains (1) summary
    cd14578
    Location:62205
    DUSP26; dual specificity protein phosphatase 26

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    33591330..33600023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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