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DUSP26 dual specificity phosphatase 26 [ Homo sapiens (human) ]

Gene ID: 78986, updated on 1-Jun-2020

Summary

Official Symbol
DUSP26provided by HGNC
Official Full Name
dual specificity phosphatase 26provided by HGNC
Primary source
HGNC:HGNC:28161
See related
Ensembl:ENSG00000133878 MIM:618368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDP4; MKP8; NEAP; DSP-4; LDP-4; MKP-8; NATA1; SKRP3; DUSP24
Summary
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Biased expression in heart (RPKM 15.4), brain (RPKM 12.7) and 8 other tissues See more
Orthologs

Genomic context

See DUSP26 in Genome Data Viewer
Location:
8p12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (33591330..33600106, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (33448848..33457546, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 122 Neighboring gene RNA, 7SL, cytoplasmic 621, pseudogene Neighboring gene uncharacterized LOC105379363 Neighboring gene BUD31 homolog pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1136, MGC2627

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoserine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoserine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 26
Names
MAP kinase phosphatase 8
Novel amplified gene in thyroid anaplastic cancer
dual specificity phosphatase 26 (putative)
dual specificity phosphatase SKRP3
low-molecular-mass dual-specificity phosphatase 4
mitogen-activated protein kinase phosphatase 8
neuroendocrine-associated phosphatase
NP_001292044.1
NP_001292045.1
NP_076930.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305115.1NP_001292044.1  dual specificity protein phosphatase 26

    See identical proteins and their annotated locations for NP_001292044.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB237597, AK055704, DA132743
    Consensus CDS
    CCDS6092.1
    UniProtKB/Swiss-Prot
    Q9BV47
    Conserved Domains (1) summary
    cd00127
    Location:61202
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. NM_001305116.1NP_001292045.1  dual specificity protein phosphatase 26

    See identical proteins and their annotated locations for NP_001292045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB237597, AC013603, BC001613, BI753746, BI834891, BP196801
    Consensus CDS
    CCDS6092.1
    UniProtKB/Swiss-Prot
    Q9BV47
    Conserved Domains (1) summary
    cd00127
    Location:61202
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  3. NM_024025.3NP_076930.1  dual specificity protein phosphatase 26

    See identical proteins and their annotated locations for NP_076930.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB237597, BC001613, DA132743
    Consensus CDS
    CCDS6092.1
    UniProtKB/Swiss-Prot
    Q9BV47
    Related
    ENSP00000256261.4, ENST00000256261.9
    Conserved Domains (1) summary
    cd00127
    Location:61202
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    33591330..33600106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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