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Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) [ Mus musculus (house mouse) ]

Gene ID: 78920, updated on 19-Feb-2019

Summary

Official Symbol
Dlstprovided by MGI
Official Full Name
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)provided by MGI
Primary source
MGI:MGI:1926170
See related
Ensembl:ENSMUSG00000004789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DLTS; 1600017E01Rik; 4632413C10Rik; 4930529O08Rik
Expression
Ubiquitous expression in heart adult (RPKM 165.8), kidney adult (RPKM 107.4) and 28 other tissues See more
Orthologs

Genomic context

See Dlst in Genome Data Viewer
Location:
12; 12 D1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (85110821..85134091)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (86451783..86475041)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene YLP motif containing 1 Neighboring gene prospero homeobox 2 opposite strand Neighboring gene prospero homeobox 2 Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene placental growth factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
dihydrolipoyllysine-residue succinyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
 
NADH metabolic process ISO
Inferred from Sequence Orthology
more info
 
histone succinylation ISO
Inferred from Sequence Orthology
more info
 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Names
2-oxoglutarate dehydrogenase complex component E2
E2K
OGDC-E2
dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
NP_084501.1
XP_006516455.1
XP_017170736.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030225.4NP_084501.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

    See identical proteins and their annotated locations for NP_084501.1

    Status: VALIDATED

    Source sequence(s)
    AK158877, AK168570, CJ308553
    Consensus CDS
    CCDS26052.1
    UniProtKB/Swiss-Prot
    Q9D2G2
    Related
    ENSMUSP00000060346.8, ENSMUST00000053811.9
    Conserved Domains (3) summary
    cd06849
    Location:72144
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01347
    Location:72454
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
    pfam00198
    Location:239452
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    85110821..85134091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516392.3XP_006516455.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1

    Conserved Domains (3) summary
    cd06849
    Location:72144
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01347
    Location:72453
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
    pfam00198
    Location:238451
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
  2. XM_017315247.1XP_017170736.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X2

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