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Dlst dihydrolipoamide S-succinyltransferase [ Mus musculus (house mouse) ]

Gene ID: 78920, updated on 3-Nov-2024

Summary

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Official Symbol
Dlstprovided by MGI
Official Full Name
dihydrolipoamide S-succinyltransferaseprovided by MGI
Primary source
MGI:MGI:1926170
See related
Ensembl:ENSMUSG00000004789 AllianceGenome:MGI:1926170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DLTS; 1600017E01Rik; 4632413C10Rik; 4930529O08Rik
Summary
Predicted to enable dihydrolipoyllysine-residue succinyltransferase activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Predicted to be involved in 2-oxoglutarate metabolic process; nucleoside phosphate metabolic process; and tricarboxylic acid cycle. Located in mitochondrion and myelin sheath. Part of oxoglutarate dehydrogenase complex. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 165.8), kidney adult (RPKM 107.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dlst in Genome Data Viewer
Location:
12 D1; 12 39.55 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85157597..85180865)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85110822..85134091)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1446 Neighboring gene STARR-seq mESC enhancer starr_32760 Neighboring gene YLP motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_32761 Neighboring gene STARR-seq mESC enhancer starr_32762 Neighboring gene prospero homeobox 2 opposite strand Neighboring gene prospero homeobox 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86464102-86464289 Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene STARR-seq mESC enhancer starr_32766 Neighboring gene placental growth factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition. Dumont M, et al. Free Radic Biol Med, 2009 Oct 1. PMID 19596066, Free PMC Article
  2. Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins. Yang L, et al. Neurobiol Dis, 2009 Nov. PMID 19660549, Free PMC Article
  3. Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity. Nilsen LH, et al. J Neurosci Res, 2011 Dec. PMID 21374701, Free PMC Article
  4. Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. Heggermont WA, et al. Circulation, 2017 Aug 22. PMID 28611091
  5. The RNA-binding protein HuR is essential for the B cell antibody response. Diaz-Muñoz MD, et al. Nat Immunol, 2015 Apr. PMID 25706746, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DLST protein levels were decreased on pressure overload in wild-type mice, but levels were maintained in microRNA-146a knock-out mice.
    Title: Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.
  2. ATP consumption is demonstrated in respiration-impaired isolated and in situ neuronal somal mitochondria from transgenic mice with a deficiency of dihydrolipoyl dehydrogenase.
    Title: The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.
  3. These results imply that diminished KGDHC activity has the potential to induce the reduction in glucose utilization that is seen in several neurodegenerative diseases.
    Title: Brain [U-13 C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity.
  4. A reduction in the DLST subunit of alpha-ketoglutarate dehydrogenase complex (KGDHC) alters the overall KGDHC activity and susceptibility to mitochondrial toxins and may contribute to the pathogenesis of neurodegenerative diseases.
    Title: Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 2-oxoglutarate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
Inferred from Electronic Annotation
more info
  
involved_in NADH metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in succinyl-CoA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of oxoadipate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oxoglutarate dehydrogenase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oxoglutarate dehydrogenase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Names
2-oxoglutarate dehydrogenase complex component E2
E2K
OGDC-E2
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
NP_084501.1
XP_006516455.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030225.4 → NP_084501.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

    See identical proteins and their annotated locations for NP_084501.1

    Status: VALIDATED

    Source sequence(s)
    AK158877, AK168570, CJ308553
    Consensus CDS
    CCDS26052.1
    UniProtKB/Swiss-Prot
    Q3UEA0, Q4FK55, Q8CIE8, Q9D2G2
    Related
    ENSMUSP00000060346.9, ENSMUST00000053811.10
    Conserved Domains (3) summary
    cd06849
    Location:72 → 144
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01347
    Location:72 → 454
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
    pfam00198
    Location:239 → 452
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    85157597..85180865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516392.5 → XP_006516455.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1

    Conserved Domains (1) summary
    TIGR01347
    Location:72 → 453
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2G2.1 GenPept UniProtKB/Swiss-Prot:Q9D2G2

Gene LinkOut

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