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Trmt44 tRNA methyltransferase 44 [ Mus musculus (house mouse) ]

Gene ID: 78890, updated on 17-Aug-2024

Summary

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Official Symbol
Trmt44provided by MGI
Official Full Name
tRNA methyltransferase 44provided by MGI
Primary source
MGI:MGI:1926140
See related
Ensembl:ENSMUSG00000029097 AllianceGenome:MGI:1926140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mettl19; 2310079F23Rik
Summary
Predicted to enable tRNA (uracil) methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be located in cytoplasm. Orthologous to human TRMT44 (tRNA methyltransferase 44 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 3.7), thymus adult (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B3; 5 18.25 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35713552..35732424, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35556208..35575080, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40283 Neighboring gene STARR-seq mESC enhancer starr_12857 Neighboring gene carboxypeptidase Z Neighboring gene polo like kinase, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_12858 Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene acyl-Coenzyme A oxidase 3, pristanoyl Neighboring gene HtrA serine peptidase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (uridine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable tRNA (uracil-O(2)-)-methyltransferase
Names
methyltransferase-like protein 19
NP_084484.2
XP_006504256.1
XP_036021511.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030208.3 → NP_084484.2  probable tRNA (uracil-O(2)-)-methyltransferase

    See identical proteins and their annotated locations for NP_084484.2

    Status: VALIDATED

    Source sequence(s)
    AC116705, AK132402
    Consensus CDS
    CCDS19230.1
    UniProtKB/Swiss-Prot
    A7MCV4, Q3V1K3, Q9D2Q2
    Related
    ENSMUSP00000030980.8, ENSMUST00000030980.12
    Conserved Domains (1) summary
    pfam07757
    Location:252 → 363
    AdoMet_MTase; Predicted AdoMet-dependent methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    35713552..35732424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165618.1 → XP_036021511.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X2

    Conserved Domains (1) summary
    pfam07757
    Location:3 → 90
    AdoMet_MTase; Predicted AdoMet-dependent methyltransferase

  2. XM_006504193.3 → XP_006504256.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X1

    Conserved Domains (1) summary
    pfam07757
    Location:80 → 191
    AdoMet_MTase; Predicted AdoMet-dependent methyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2Q2.2 GenPept UniProtKB/Swiss-Prot:Q9D2Q2

Gene LinkOut

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