MAPKAPK3 MAPK activated protein kinase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPKAPK3provided by HGNC
Official Full Name: MAPK activated protein kinase 3provided by HGNC
Primary source: HGNC:HGNC:6888
See related: Ensembl:ENSG00000114738 MIM:602130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 3PK; MK3; MK-3; MDPT3; MAPKAP3; MAPKAP-K3; MAPKAPK-3
Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Expression: Broad expression in heart (RPKM 55.1), bone marrow (RPKM 29.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p21.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	3	NC_000003.12 (50611877..50649291)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (50649308..50686722)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The natural history of MCRPE is in relation to the role of MAPKAPK3 in BM modeling, vascular endothelial growth factor activity, retinal pigment epithelial responses
Title: Martinique Crinkled Retinal Pigment Epitheliopathy: Clinical Stages and Pathophysiologic Insights.
A dominant mutation in MAPKAPK3 causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium.
Title: A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium.
MK3 modulation affects BMI1-dependent and independent cell cycle check-points
Title: MK3 modulation affects BMI1-dependent and independent cell cycle check-points.
findings reveal MK2/MK3 as crucial stress-responsive kinases that promote autophagy through Beclin 1 S90 phosphorylation
Title: The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation.
Hepatitis C virus core protein interacted with MAPKAPK3 through amino acid residues 41 to 75 of core and the N-terminal half of kinase domain of MAPKAPK3.
Title: Modulation of mitogen-activated protein kinase-activated protein kinase 3 by hepatitis C virus core protein.
Identified CREB activators MAPKAPK3 and FHL5 as mediators of intimal hyperplasia in vein graft samples.
Title: Cyclic adenosine monophosphate response-element binding protein activation by mitogen-activated protein kinase-activated protein kinase 3 and four-and-a-half LIM domains 5 plays a key role for vein graft intimal hyperplasia.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
A high-resolution (1.9 A) crystal structure of the highly homologous MK3 in complex with a pharmaceutical lead compound is presented.
Title: High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Macular dystrophy, patterned, 3 MedGen: C4310713 OMIM: 617111 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC22669P2 (e-PCR)
- UniSTS:272132

RH93496 (e-PCR)
- UniSTS:86638

MAPKAPK3__7370 (e-PCR)
- UniSTS:466295

RH70632 (e-PCR)
- UniSTS:44169

WI-13560 (e-PCR)
- UniSTS:76766

PMC22669P1 (e-PCR)
- UniSTS:272121

Homology

Homologs of the MAPKAPK3 gene: The MAPKAPK3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 392 organisms have orthologs with human gene MAPKAPK3
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	TAS Traceable Author Statement more info	PubMed
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables mitogen-activated protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in macropinocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to cytokine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: MAP kinase-activated protein kinase 3

Names: MAPKAP kinase 3; chromosome 3p kinase; mitogen-activated protein kinase-activated protein kinase 3

NP_001230854.1

EC 2.7.11.1

NP_001230855.1

EC 2.7.11.1

NP_004626.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051548.1 RefSeqGene

Range

5001..42436

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001243925.2 → NP_001230854.1 MAP kinase-activated protein kinase 3

See identical proteins and their annotated locations for NP_001230854.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC096920, BE301676, BM848086, U09578

Consensus CDS

CCDS2832.1

UniProtKB/Swiss-Prot

Q16644

UniProtKB/TrEMBL

A0A024R2W7

Related

ENSP00000478922.1, ENST00000621469.5

Conserved Domains (1) summary

cd14172
Location:39 → 304

STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3
NM_001243926.2 → NP_001230855.1 MAP kinase-activated protein kinase 3

See identical proteins and their annotated locations for NP_001230855.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC096920, BC068497, BE301676, DB450001

Consensus CDS

CCDS2832.1

UniProtKB/Swiss-Prot

Q16644

UniProtKB/TrEMBL

A0A024R2W7

Related

ENSP00000396467.1, ENST00000446044.5

Conserved Domains (1) summary

cd14172
Location:39 → 304

STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3
NM_004635.5 → NP_004626.1 MAP kinase-activated protein kinase 3

See identical proteins and their annotated locations for NP_004626.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC096920, BC001662, BE301676, BM848086

Consensus CDS

CCDS2832.1

UniProtKB/Swiss-Prot

Q16644

UniProtKB/TrEMBL

A0A024R2W7

Related

ENSP00000350639.2, ENST00000357955.6

Conserved Domains (1) summary

cd14172
Location:39 → 304

STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3