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MAPKAPK3 MAPK activated protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 7867, updated on 24-Nov-2020

Summary

Official Symbol
MAPKAPK3provided by HGNC
Official Full Name
MAPK activated protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:6888
See related
Ensembl:ENSG00000114738 MIM:602130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
3PK; MK3; MK-3; MDPT3; MAPKAP3; MAPKAP-K3; MAPKAPK-3
Summary
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Expression
Broad expression in heart (RPKM 55.1), bone marrow (RPKM 29.6) and 25 other tissues See more
Orthologs

Genomic context

See MAPKAPK3 in Genome Data Viewer
Location:
3p21.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (50611877..50649291)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50649293..50686728)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1747 Neighboring gene cytokine inducible SH2 containing protein Neighboring gene long intergenic non-protein coding RNA 2019 Neighboring gene microRNA 4787 Neighboring gene dedicator of cytokinesis 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity TAS
Traceable Author Statement
more info
PubMed 
calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macropinocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MAP kinase-activated protein kinase 3
Names
MAPKAP kinase 3
chromosome 3p kinase
mitogen-activated protein kinase-activated protein kinase 3
NP_001230854.1
NP_001230855.1
NP_004626.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051548.1 RefSeqGene

    Range
    5001..42436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243925.2NP_001230854.1  MAP kinase-activated protein kinase 3

    See identical proteins and their annotated locations for NP_001230854.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC096920, BE301676, BM848086, U09578
    Consensus CDS
    CCDS2832.1
    UniProtKB/Swiss-Prot
    Q16644
    UniProtKB/TrEMBL
    A0A024R2W7
    Related
    ENSP00000478922.1, ENST00000621469.5
    Conserved Domains (1) summary
    cd14172
    Location:39304
    STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3
  2. NM_001243926.2NP_001230855.1  MAP kinase-activated protein kinase 3

    See identical proteins and their annotated locations for NP_001230855.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC096920, BC068497, BE301676, DB450001
    Consensus CDS
    CCDS2832.1
    UniProtKB/Swiss-Prot
    Q16644
    UniProtKB/TrEMBL
    A0A024R2W7
    Related
    ENSP00000396467.1, ENST00000446044.5
    Conserved Domains (1) summary
    cd14172
    Location:39304
    STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3
  3. NM_004635.5NP_004626.1  MAP kinase-activated protein kinase 3

    See identical proteins and their annotated locations for NP_004626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC096920, BC001662, BE301676, BM848086
    Consensus CDS
    CCDS2832.1
    UniProtKB/Swiss-Prot
    Q16644
    UniProtKB/TrEMBL
    A0A024R2W7
    Related
    ENSP00000350639.2, ENST00000357955.6
    Conserved Domains (1) summary
    cd14172
    Location:39304
    STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    50611877..50649291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_940501.2 RNA Sequence

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