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ZP3 zona pellucida glycoprotein 3 [ Homo sapiens (human) ]

Gene ID: 7784, updated on 7-Jun-2020

Summary

Official Symbol
ZP3provided by HGNC
Official Full Name
zona pellucida glycoprotein 3provided by HGNC
Primary source
HGNC:HGNC:13189
See related
Ensembl:ENSG00000188372 MIM:182889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZPC; ZP3A; ZP3B; Zp-3; OOMD3
Summary
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 5.0), skin (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See ZP3 in Genome Data Viewer
Location:
7q11.23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (76397522..76442069)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76026841..76071388)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene heat shock protein family B (small) member 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene Sharpr-MPRA regulatory region 7220 Neighboring gene deltex E3 ubiquitin ligase 2 Neighboring gene farnesyl diphosphate synthase pseudogene 2 Neighboring gene uroplakin 3B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acrosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acrosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix structural constituent HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor ligand activity ISS
Inferred from Sequence or Structural Similarity
more info
 
structural constituent of egg coat IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
binding of sperm to zona pellucida IDA
Inferred from Direct Assay
more info
PubMed 
binding of sperm to zona pellucida IGI
Inferred from Genetic Interaction
more info
PubMed 
binding of sperm to zona pellucida IMP
Inferred from Mutant Phenotype
more info
PubMed 
binding of sperm to zona pellucida TAS
Traceable Author Statement
more info
 
blastocyst formation ISS
Inferred from Sequence or Structural Similarity
more info
 
egg coat formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
egg coat formation ISS
Inferred from Sequence or Structural Similarity
more info
 
humoral immune response mediated by circulating immunoglobulin ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of binding of sperm to zona pellucida IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
oocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of acrosomal vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of acrosomal vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of acrosome reaction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of antral ovarian follicle growth ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of humoral immune response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of leukocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ovarian follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of type IV hypersensitivity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
egg coat IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zona pellucida sperm-binding protein 3
Names
ZP3A/ZP3B
sperm receptor
zona pellucida glycoprotein 3B
zona pellucida glycoprotein ZP3
zona pellucida protein C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033938.1 RefSeqGene

    Range
    4999..49546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001110354.2NP_001103824.1  zona pellucida sperm-binding protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001103824.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC005522, BC113949, DB328313, M60504
    Consensus CDS
    CCDS47618.1
    UniProtKB/Swiss-Prot
    P21754
    Related
    ENSP00000378326.3, ENST00000394857.8
    Conserved Domains (2) summary
    smart00241
    Location:45303
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:187301
    Zona_pellucida; Zona pellucida-like domain
  2. NM_007155.6NP_009086.4  zona pellucida sperm-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_009086.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' CDS compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC005522, AK292763, BC113949, DB328313
    Consensus CDS
    CCDS5586.1
    UniProtKB/Swiss-Prot
    P21754
    Related
    ENSP00000337310.4, ENST00000336517.8
    Conserved Domains (2) summary
    smart00241
    Location:2252
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:136250
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    76397522..76442069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012586.2XP_016868075.1  zona pellucida sperm-binding protein 3 isoform X1

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