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SLC30A3 solute carrier family 30 member 3 [ Homo sapiens (human) ]

Gene ID: 7781, updated on 17-Jun-2019

Summary

Official Symbol
SLC30A3provided by HGNC
Official Full Name
solute carrier family 30 member 3provided by HGNC
Primary source
HGNC:HGNC:11014
See related
Ensembl:ENSG00000115194 MIM:602878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNT3
Expression
Biased expression in testis (RPKM 9.2), brain (RPKM 7.3) and 1 other tissue See more
Orthologs

Genomic context

See SLC30A3 in Genome Data Viewer
Location:
2p23.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27253684..27275863, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27477440..27501093, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 6 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene tripartite motif containing 54 Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc-transporting ATPase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transport IEA
Inferred from Electronic Annotation
more info
 
regulation of sequestering of zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of sequestering of zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion import into synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endosome TAS
Traceable Author Statement
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc transporter 3
Names
solute carrier family 30 (zinc transporter), member 3
zinc transporter ZnT-3
znT-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318949.2NP_001305878.1  zinc transporter 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC013413, AK302174, BC028358, DB034101
    UniProtKB/Swiss-Prot
    Q99726
    UniProtKB/TrEMBL
    B4DXX8
    Conserved Domains (2) summary
    TIGR01297
    Location:80367
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:80288
    Cation_efflux; Cation efflux family
  2. NM_001318950.1NP_001305879.1  zinc transporter 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    BC028358, BM554028
    UniProtKB/Swiss-Prot
    Q99726
    Conserved Domains (1) summary
    TIGR01297
    Location:72359
    CDF; cation diffusion facilitator family transporter
  3. NM_001318951.2NP_001305880.1  zinc transporter 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC013413, BC028358, DB034101
    UniProtKB/Swiss-Prot
    Q99726
    Conserved Domains (1) summary
    TIGR01297
    Location:72359
    CDF; cation diffusion facilitator family transporter
  4. NM_003459.5NP_003450.2  zinc transporter 3 isoform a

    See identical proteins and their annotated locations for NP_003450.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC013413, BC028358
    Consensus CDS
    CCDS1743.1
    UniProtKB/Swiss-Prot
    Q99726
    Related
    ENSP00000233535.4, ENST00000233535.8
    Conserved Domains (1) summary
    TIGR01297
    Location:85372
    CDF; cation diffusion facilitator family transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27253684..27275863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533102.2XP_011531404.1  zinc transporter 3 isoform X5

    Related
    ENSP00000388219.1, ENST00000445870.5
    Conserved Domains (2) summary
    TIGR01297
    Location:154299
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:154220
    Cation_efflux; Cation efflux family
  2. XM_017004874.1XP_016860363.1  zinc transporter 3 isoform X3

  3. XM_005264548.3XP_005264605.1  zinc transporter 3 isoform X2

    Conserved Domains (1) summary
    pfam01545
    Location:80137
    Cation_efflux; Cation efflux family
  4. XM_017004873.1XP_016860362.1  zinc transporter 3 isoform X3

  5. XM_017004875.2XP_016860364.1  zinc transporter 3 isoform X4

    Conserved Domains (1) summary
    pfam01545
    Location:63120
    Cation_efflux; Cation efflux family
  6. XM_011533103.2XP_011531405.1  zinc transporter 3 isoform X6

    Conserved Domains (2) summary
    TIGR01297
    Location:113258
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:113179
    Cation_efflux; Cation efflux family
  7. XM_005264547.2XP_005264604.1  zinc transporter 3 isoform X1

    Conserved Domains (1) summary
    pfam01545
    Location:85142
    Cation_efflux; Cation efflux family
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