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SLC30A3 solute carrier family 30 member 3 [ Homo sapiens (human) ]

Gene ID: 7781, updated on 22-Sep-2022

Summary

Official Symbol
SLC30A3provided by HGNC
Official Full Name
solute carrier family 30 member 3provided by HGNC
Primary source
HGNC:HGNC:11014
See related
Ensembl:ENSG00000115194 MIM:602878; AllianceGenome:HGNC:11014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNT3
Summary
Predicted to enable zinc ion transmembrane transporter activity. Involved in regulation of sequestering of zinc ion. Located in late endosome and synaptic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 9.2), brain (RPKM 7.3) and 1 other tissue See more
Orthologs
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Genomic context

See SLC30A3 in Genome Data Viewer
Location:
2p23.3
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27253684..27275817, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27295330..27317459, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27476552..27498685, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 6 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene tripartite motif containing 54 Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion transmembrane transporter activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sequestering of zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of sequestering of zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in zinc ion import into synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in zinc ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc transporter 3
Names
solute carrier family 30 (zinc transporter), member 3
zinc transporter ZnT-3
znT-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318949.2NP_001305878.1  zinc transporter 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC013413, AK302174, BC028358, DB034101
    UniProtKB/Swiss-Prot
    Q99726
    UniProtKB/TrEMBL
    B4DXX8
    Conserved Domains (1) summary
    TIGR01297
    Location:80367
    CDF; cation diffusion facilitator family transporter
  2. NM_001318950.2NP_001305879.1  zinc transporter 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC013413, BC028358, BM554028
    UniProtKB/Swiss-Prot
    Q99726
    Conserved Domains (1) summary
    TIGR01297
    Location:72359
    CDF; cation diffusion facilitator family transporter
  3. NM_001318951.2NP_001305880.1  zinc transporter 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC013413, BC028358, DB034101
    UniProtKB/Swiss-Prot
    Q99726
    Conserved Domains (1) summary
    TIGR01297
    Location:72359
    CDF; cation diffusion facilitator family transporter
  4. NM_003459.5NP_003450.2  zinc transporter 3 isoform a

    See identical proteins and their annotated locations for NP_003450.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC013413, BC028358
    Consensus CDS
    CCDS1743.1
    UniProtKB/Swiss-Prot
    Q8TC03, Q99726
    Related
    ENSP00000233535.4, ENST00000233535.9
    Conserved Domains (1) summary
    TIGR01297
    Location:85372
    CDF; cation diffusion facilitator family transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    27253684..27275817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004874.2XP_016860363.1  zinc transporter 3 isoform X3

    Conserved Domains (1) summary
    TIGR01297
    Location:72129
    CDF; cation diffusion facilitator family transporter
  2. XM_011533102.3XP_011531404.1  zinc transporter 3 isoform X6

    Conserved Domains (2) summary
    TIGR01297
    Location:154299
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:154220
    Cation_efflux; Cation efflux family
  3. XM_047445785.1XP_047301741.1  zinc transporter 3 isoform X2

  4. XM_047445786.1XP_047301742.1  zinc transporter 3 isoform X5

  5. XM_017004873.2XP_016860362.1  zinc transporter 3 isoform X3

    Conserved Domains (1) summary
    TIGR01297
    Location:72129
    CDF; cation diffusion facilitator family transporter
  6. XM_047445787.1XP_047301743.1  zinc transporter 3 isoform X6

    Related
    ENSP00000388219.1, ENST00000445870.5
  7. XM_005264548.4XP_005264605.1  zinc transporter 3 isoform X2

    Conserved Domains (1) summary
    pfam01545
    Location:80137
    Cation_efflux; Cation efflux family
  8. XM_017004875.3XP_016860364.1  zinc transporter 3 isoform X4

    Conserved Domains (1) summary
    pfam01545
    Location:63120
    Cation_efflux; Cation efflux family
  9. XM_005264547.3XP_005264604.1  zinc transporter 3 isoform X1

    Conserved Domains (1) summary
    pfam01545
    Location:85142
    Cation_efflux; Cation efflux family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27295330..27317459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)