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SLC30A2 solute carrier family 30 member 2 [ Homo sapiens (human) ]

Gene ID: 7780, updated on 21-Jun-2020

Summary

Official Symbol
SLC30A2provided by HGNC
Official Full Name
solute carrier family 30 member 2provided by HGNC
Primary source
HGNC:HGNC:11013
See related
Ensembl:ENSG00000158014 MIM:609617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNZD; ZNT2; ZnT-2; PP12488
Summary
The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Expression
Biased expression in thyroid (RPKM 19.5), kidney (RPKM 11.8) and 4 other tissues See more
Orthologs

Genomic context

See SLC30A2 in Genome Data Viewer
Location:
1p36.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (26037252..26046118, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26364513..26373439, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene platelet activating factor acetylhydrolase 2 Neighboring gene RNA, U6 small nuclear 110, pseudogene Neighboring gene uncharacterized LOC101928216 Neighboring gene exostosin like glycosyltransferase 1 Neighboring gene uncharacterized LOC105376910 Neighboring gene tripartite motif containing 63

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36708, MGC11303

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of sequestering of zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sequestering of zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc transporter 2
Names
solute carrier family 30 (zinc transporter), member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042808.1 RefSeqGene

    Range
    5021..13887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004434.3NP_001004434.1  zinc transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_001004434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF370409, AI161067, AL391650, DR004258
    Consensus CDS
    CCDS30644.1
    UniProtKB/Swiss-Prot
    Q9BRI3
    Related
    ENSP00000363394.3, ENST00000374276.4
    Conserved Domains (2) summary
    TIGR01297
    Location:83357
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:83278
    Cation_efflux; Cation efflux family
  2. NM_032513.5NP_115902.1  zinc transporter 2 isoform 2

    See identical proteins and their annotated locations for NP_115902.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF370409, AI161067, AL391650, BC006251, DR004258
    Consensus CDS
    CCDS272.1
    UniProtKB/Swiss-Prot
    Q9BRI3
    Related
    ENSP00000363396.3, ENST00000374278.7
    Conserved Domains (1) summary
    TIGR01297
    Location:91308
    CDF; cation diffusion facilitator family transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    26037252..26046118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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