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H2az2 H2A.Z histone variant 2 [ Mus musculus (house mouse) ]

Gene ID: 77605, updated on 21-Apr-2024

Summary

Official Symbol
H2az2provided by MGI
Official Full Name
H2A.Z histone variant 2provided by MGI
Primary source
MGI:MGI:1924855
See related
Ensembl:ENSMUSG00000041126 AllianceGenome:MGI:1924855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2av; H2afv; H2A.Z2; H2a.z-2; Wnt1cre; Wnt1-Cre; Wnt1::Cre; C530002L11Rik; Tg(Wnt1-cre)11Rth
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 129.3), CNS E14 (RPKM 78.5) and 27 other tissues See more
Orthologs
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Genomic context

Location:
11 A1; 11 4.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6377226..6394511, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6427226..6444511, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene microRNA 7651 Neighboring gene STARR-seq mESC enhancer starr_28463 Neighboring gene STARR-positive B cell enhancer ABC_E5206 Neighboring gene peptidylprolyl isomerase A Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:6344510-6344697 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene 11971

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H2A.V
Names
H2A histone family, member V
H2A.Z variant histone 2
histone H2A.F/Z

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347064.1NP_001333993.1  histone H2A.V isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AI851486, AL646020, BC028539, CJ069840
    Consensus CDS
    CCDS83779.1
    UniProtKB/TrEMBL
    Q5NC91, Q8R029
    Related
    ENSMUSP00000091037.6, ENSMUST00000093346.6
    Conserved Domains (1) summary
    PTZ00017
    Location:390
    PTZ00017; histone H2A; Provisional
  2. NM_029938.1NP_084214.1  histone H2A.V isoform 1

    See identical proteins and their annotated locations for NP_084214.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL646020, BC147294, CJ069840
    Consensus CDS
    CCDS48750.1
    UniProtKB/Swiss-Prot
    Q3THW5, Q5NC92, Q6ZWU0
    UniProtKB/TrEMBL
    B2RVP5
    Related
    ENSMUSP00000105359.3, ENSMUST00000109737.9
    Conserved Domains (1) summary
    PLN00154
    Location:6121
    PLN00154; histone H2A; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6377226..6394511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246426.2XP_030102286.1  histone H2A.V isoform X1

    Conserved Domains (1) summary
    PLN00154
    Location:30124
    PLN00154; histone H2A; Provisional