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H2az2 H2A.Z histone variant 2 [ Mus musculus (house mouse) ]

Gene ID: 77605, updated on 2-Jul-2024

Summary

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Official Symbol
H2az2provided by MGI
Official Full Name
H2A.Z histone variant 2provided by MGI
Primary source
MGI:MGI:1924855
See related
Ensembl:ENSMUSG00000041126 AllianceGenome:MGI:1924855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2av; H2afv; H2A.Z2; H2a.z-2; Wnt1cre; Wnt1-Cre; Wnt1::Cre; C530002L11Rik; Tg(Wnt1-cre)11Rth
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 129.3), CNS E14 (RPKM 78.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See H2az2 in Genome Data Viewer
Location:
11 A1; 11 4.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6377226..6394511, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6427226..6444511, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene microRNA 7651 Neighboring gene STARR-seq mESC enhancer starr_28463 Neighboring gene STARR-positive B cell enhancer ABC_E5206 Neighboring gene peptidylprolyl isomerase A Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:6344510-6344697 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene 11971

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration. Inagaki E, et al. Stem Cells Transl Med, 2017 Mar. PMID 28186681, Free PMC Article
  2. Adipose stromal cells contain phenotypically distinct adipogenic progenitors derived from neural crest. Sowa Y, et al. PLoS One, 2013. PMID 24391913, Free PMC Article
  3. Temporal and Spatial Cellular Distribution of Neural Crest Derivatives and Alpha Cells during Islet Development. Shimada K, et al. Acta Histochem Cytochem, 2012 Feb 29. PMID 22489106, Free PMC Article
  4. Divergent fate and origin of neurosphere-like bodies from different layers of the gut. Becker L, et al. Am J Physiol Gastrointest Liver Physiol, 2012 May 1. PMID 22361728, Free PMC Article
  5. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Smukler SR, et al. Cell Stem Cell, 2011 Mar 4. PMID 21362568

See all (810) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis.
    Title: Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis.
  2. Histone H2A.Z is required for androgen receptor-mediated effects on fear memory.
    Title: Histone H2A.Z is required for androgen receptor-mediated effects on fear memory.
  3. Histone variant dictates fate biasing of neural crest cells to melanocyte lineage.
    Title: Histone variant dictates fate biasing of neural crest cells to melanocyte lineage.
  4. Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells.
    Title: Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells.
  5. H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles.
    Title: H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles.
  6. H2A.Z.2 expression is closely associated with microglia embryonic development. A key role of H2A.Z.2 in neural progenitor cells in controlling microglial development.H2A.Z.2- and G9a-mediated H3K9me2 modifications regulate Cxcl14 transcription in microglial embryonic development.
    Title: Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone H2A.V
Names
H2A histone family, member V
H2A.Z variant histone 2
histone H2A.F/Z

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347064.1 → NP_001333993.1  histone H2A.V isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AI851486, AL646020, BC028539, CJ069840
    Consensus CDS
    CCDS83779.1
    UniProtKB/TrEMBL
    Q5NC91, Q8R029
    Related
    ENSMUSP00000091037.6, ENSMUST00000093346.6
    Conserved Domains (1) summary
    PTZ00017
    Location:3 → 90
    PTZ00017; histone H2A; Provisional

  2. NM_029938.1 → NP_084214.1  histone H2A.V isoform 1

    See identical proteins and their annotated locations for NP_084214.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL646020, BC147294, CJ069840
    Consensus CDS
    CCDS48750.1
    UniProtKB/Swiss-Prot
    Q3THW5, Q5NC92, Q6ZWU0
    UniProtKB/TrEMBL
    B2RVP5
    Related
    ENSMUSP00000105359.3, ENSMUST00000109737.9
    Conserved Domains (1) summary
    PLN00154
    Location:6 → 121
    PLN00154; histone H2A; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6377226..6394511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246426.2 → XP_030102286.1  histone H2A.V isoform X1

    Conserved Domains (1) summary
    PLN00154
    Location:30 → 124
    PLN00154; histone H2A; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3THW5.3 GenPept UniProtKB/Swiss-Prot:Q3THW5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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