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Slitrk1 SLIT and NTRK-like family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 76965, updated on 11-Apr-2024

Summary

Official Symbol
Slitrk1provided by MGI
Official Full Name
SLIT and NTRK-like family, member 1provided by MGI
Primary source
MGI:MGI:2679446
See related
Ensembl:ENSMUSG00000075478 AllianceGenome:MGI:2679446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3200001I04Rik
Summary
Acts upstream of or within several processes, including adult behavior; axonogenesis; and positive regulation of synapse assembly. Located in glutamatergic synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; limb mesenchyme; and reproductive system. Used to study Gilles de la Tourette syndrome. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and trichotillomania. Orthologous to human SLITRK1 (SLIT and NTRK like family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Slitrk1 in Genome Data Viewer
Location:
14 E3; 14 56.78 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (109147420..109151671, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (108909988..108914239, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24229 Neighboring gene ribosomal protein L27A, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_37564 Neighboring gene STARR-seq mESC enhancer starr_37565 Neighboring gene STARR-seq mESC enhancer starr_37566 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene predicted gene, 30216

Genomic regions, transcripts, and products

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SLIT and NTRK-like protein 1
Names
slit and trk like gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199065.2NP_951020.1  SLIT and NTRK-like protein 1 precursor

    See identical proteins and their annotated locations for NP_951020.1

    Status: VALIDATED

    Source sequence(s)
    AK173296, BE956915, CO430912
    Consensus CDS
    CCDS27325.1
    UniProtKB/Swiss-Prot
    Q810C1, Q9CXL0
    UniProtKB/TrEMBL
    B2RXM1, Q69Z70
    Related
    ENSMUSP00000097897.3, ENSMUST00000100322.4
    Conserved Domains (3) summary
    sd00033
    Location:6283
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:425483
    LRR_8; Leucine rich repeat
    cl15307
    Location:212250
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    109147420..109151671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)