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Rbm17 RNA binding motif protein 17 [ Mus musculus (house mouse) ]

Gene ID: 76938, updated on 8-Feb-2024

Summary

Official Symbol
Rbm17provided by MGI
Official Full Name
RNA binding motif protein 17provided by MGI
Primary source
MGI:MGI:1924188
See related
Ensembl:ENSMUSG00000037197 AllianceGenome:MGI:1924188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700027J02Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Located in nucleus. Part of protein-containing complex. Is expressed in brain; ovary; and primary sex cord. Orthologous to human RBM17 (RNA binding motif protein 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 55.4), CNS E14 (RPKM 34.1) and 25 other tissues See more
Orthologs
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Genomic context

See Rbm17 in Genome Data Viewer
Location:
2 A1; 2 8.85 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11590250..11608061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11585439..11603199, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Neighboring gene STARR-seq mESC enhancer starr_03667 Neighboring gene predicted gene, 52500 Neighboring gene STARR-seq mESC enhancer starr_03668 Neighboring gene predicted gene 10851 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11470208-11470361 Neighboring gene STARR-positive B cell enhancer mm9_chr2:11475523-11475823 Neighboring gene STARR-seq mESC enhancer starr_03673 Neighboring gene STARR-positive B cell enhancer ABC_E5883 Neighboring gene STARR-seq mESC enhancer starr_03674 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11558884-11559067 Neighboring gene STARR-positive B cell enhancer ABC_E9504 Neighboring gene STARR-positive B cell enhancer ABC_E5884 Neighboring gene STARR-positive B cell enhancer ABC_E5885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11577075-11577258 Neighboring gene interleukin 2 receptor, alpha chain Neighboring gene STARR-seq mESC enhancer starr_03676 Neighboring gene predicted gene, 39760

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA splicing, via transesterification reactions TAS
Traceable Author Statement
more info
PubMed 
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
splicing factor 45
Names
45 kDa-splicing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418858.1NP_001405787.1  splicing factor 45 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL831794
  2. NM_001418859.1NP_001405788.1  splicing factor 45 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL831794
  3. NM_152824.2NP_690037.1  splicing factor 45 isoform 1

    See identical proteins and their annotated locations for NP_690037.1

    Status: VALIDATED

    Source sequence(s)
    AL831794
    Consensus CDS
    CCDS15684.1
    UniProtKB/Swiss-Prot
    A2AP41, O75939, Q8JZX4
    Related
    ENSMUSP00000041831.6, ENSMUST00000040314.12
    Conserved Domains (2) summary
    cd12647
    Location:307401
    RRM_UHM_SPF45; RNA recognition motif in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
    pfam01585
    Location:235275
    G-patch; G-patch domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    11590250..11608061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940770.1 RNA Sequence