U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cers2 ceramide synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 76893, updated on 21-Apr-2024

Summary

Official Symbol
Cers2provided by MGI
Official Full Name
ceramide synthase 2provided by MGI
Primary source
MGI:MGI:1924143
See related
Ensembl:ENSMUSG00000015714 AllianceGenome:MGI:1924143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRH3; Lass2; 0610013I17Rik
Summary
Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process and regulation of lipid metabolic process. Acts upstream of or within sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in epidermis stratum basale; epidermis stratum spinosum; limb; liver; and neural tube. Orthologous to human CERS2 (ceramide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 73.3), placenta adult (RPKM 50.3) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
3 F2.1; 3 40.74 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95222077..95230910)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95314771..95323599)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene SET domain, bifurcated 1 Neighboring gene STARR-seq mESC enhancer starr_08380 Neighboring gene STARR-positive B cell enhancer mm9_chr3:95161130-95161430 Neighboring gene predicted gene, 37500 Neighboring gene cortexin domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables N-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphingosine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sphingosine N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sphingosine N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ceramide synthase 2
Names
LAG1 homolog, ceramide synthase 2
LAG1 longevity assurance homolog 2
TRAM homolog 3
longevity assurance homolog 2
sphingosine N-acyltransferase CERS2
translocating chain-associating membrane protein homolog 3
tumor metastasis-suppressor gene 1 protein
very-long-chain ceramide synthase CERS2
NP_001307421.1
NP_084065.1
XP_006502323.1
XP_030108738.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320492.1NP_001307421.1  ceramide synthase 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC140190, AK159325, BQ176425, BY773771, DN176473
    Consensus CDS
    CCDS17612.1
    UniProtKB/Swiss-Prot
    Q3TXC5, Q924Z4, Q9DCN6
    Conserved Domains (2) summary
    smart00724
    Location:131332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:71128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_029789.2NP_084065.1  ceramide synthase 2

    See identical proteins and their annotated locations for NP_084065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein
    Source sequence(s)
    AC140190, AK159325, BQ176425, CD564737
    Consensus CDS
    CCDS17612.1
    UniProtKB/Swiss-Prot
    Q3TXC5, Q924Z4, Q9DCN6
    Related
    ENSMUSP00000015858.5, ENSMUST00000015858.12
    Conserved Domains (2) summary
    smart00724
    Location:131332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:71128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95222077..95230910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502260.3XP_006502323.1  ceramide synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006502323.1

    UniProtKB/Swiss-Prot
    Q3TXC5, Q924Z4, Q9DCN6
    Conserved Domains (2) summary
    smart00724
    Location:131332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:71128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. XM_030252878.1XP_030108738.1  ceramide synthase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TXC5, Q924Z4, Q9DCN6
    Conserved Domains (2) summary
    smart00724
    Location:131332
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:71128
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.