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Hyls1 HYLS1, centriolar and ciliogenesis associated [ Mus musculus (house mouse) ]

Gene ID: 76832, updated on 30-Apr-2024

Summary

Official Symbol
Hyls1provided by MGI
Official Full Name
HYLS1, centriolar and ciliogenesis associatedprovided by MGI
Primary source
MGI:MGI:1924082
See related
Ensembl:ENSMUSG00000050555 AllianceGenome:MGI:1924082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3010015K02Rik
Summary
Predicted to be involved in cilium assembly. Predicted to act upstream of or within cell projection organization. Predicted to be located in several cellular components, including centrosome; cytosol; and nucleus. Predicted to be active in centriole and non-motile cilium. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hydrolethalus syndrome 1. Orthologous to human HYLS1 (HYLS1 centriolar and ciliogenesis associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 18.2), CNS E11.5 (RPKM 6.8) and 17 other tissues See more
Orthologs
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Genomic context

See Hyls1 in Genome Data Viewer
Location:
9 A4; 9 20.32 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35472117..35481365, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35560821..35570069, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E11404 Neighboring gene DEAD box helicase 25 Neighboring gene pseudouridine synthase 3 Neighboring gene STARR-positive B cell enhancer ABC_E1782 Neighboring gene small cell adhesion glycoprotein family member Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
centriolar and ciliogenesis-associated protein HYLS1
Names
hydrolethalus syndrome 1
hydrolethalus syndrome protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029762.1NP_084038.1  centriolar and ciliogenesis-associated protein HYLS1

    See identical proteins and their annotated locations for NP_084038.1

    Status: VALIDATED

    Source sequence(s)
    AK013896, AK131639, BY109268
    Consensus CDS
    CCDS52754.1
    UniProtKB/Swiss-Prot
    Q3V2R4, Q8CI83, Q9CXX0
    UniProtKB/TrEMBL
    A0A0R4J1K7
    Related
    ENSMUSP00000110762.4, ENSMUST00000115110.5
    Conserved Domains (1) summary
    pfam15311
    Location:213299
    HYLS1_C; Hydrolethalus syndrome protein 1 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35472117..35481365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)