U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ckmt2 creatine kinase, mitochondrial 2 [ Mus musculus (house mouse) ]

Gene ID: 76722, updated on 21-May-2024

Summary

Official Symbol
Ckmt2provided by MGI
Official Full Name
creatine kinase, mitochondrial 2provided by MGI
Primary source
MGI:MGI:1923972
See related
Ensembl:ENSMUSG00000021622 AllianceGenome:MGI:1923972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S-MtCK; mib-CK; ScCKmit; 2300008A19Rik
Summary
Predicted to enable cardiolipin binding activity and creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphocreatine metabolic process. Located in mitochondrion. Is expressed in several structures, including gut; heart; lung; metanephros; and thymus. Orthologous to human CKMT2 (creatine kinase, mitochondrial 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 839.5) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ckmt2 in Genome Data Viewer
Location:
13 C3; 13 47.43 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (92001510..92025001, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (91853386..91876923, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833422C13 gene Neighboring gene STARR-seq mESC enhancer starr_35256 Neighboring gene acyl-CoA thioesterase 12 Neighboring gene STARR-positive B cell enhancer ABC_E5409 Neighboring gene STARR-positive B cell enhancer ABC_E4085 Neighboring gene STARR-seq mESC enhancer starr_35257 Neighboring gene STARR-seq mESC enhancer starr_35258 Neighboring gene zinc finger, CCHC domain containing 9 Neighboring gene RAS protein-specific guanine nucleotide-releasing factor 2 Neighboring gene predicted gene, 46435 Neighboring gene STARR-seq mESC enhancer starr_35260 Neighboring gene STARR-seq mESC enhancer starr_35261 Neighboring gene STARR-seq mESC enhancer starr_35262 Neighboring gene mutS homolog 3 Neighboring gene predicted gene, 20379

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cardiolipin binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables creatine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables creatine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in phosphocreatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphocreatine metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
creatine kinase S-type, mitochondrial
Names
basic-type mitochondrial creatine kinase
sarcomeric mitochondrial creatine kinase
NP_940807.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198415.4NP_940807.1  creatine kinase S-type, mitochondrial precursor

    See identical proteins and their annotated locations for NP_940807.1

    Status: VALIDATED

    Source sequence(s)
    AC167972
    Consensus CDS
    CCDS26679.1
    UniProtKB/Swiss-Prot
    Q6P8J7
    Related
    ENSMUSP00000022122.4, ENSMUST00000022122.4
    Conserved Domains (1) summary
    cd00716
    Location:50407
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    92001510..92025001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)