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Kansl1 KAT8 regulatory NSL complex subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 76719, updated on 8-Dec-2022

Summary

Official Symbol
Kansl1provided by MGI
Official Full Name
KAT8 regulatory NSL complex subunit 1provided by MGI
Primary source
MGI:MGI:1923969
See related
Ensembl:ENSMUSG00000018412 AllianceGenome:MGI:1923969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1267; 1700081L11Rik; 9430041J06Rik
Summary
Predicted to enable histone acetyltransferase binding activity. Predicted to be involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleoplasm. Predicted to be part of MLL1 complex and NSL complex. Is expressed in brain. Human ortholog(s) of this gene implicated in Koolen de Vries syndrome. Orthologous to human KANSL1 (KAT8 regulatory NSL complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 26.5), ovary adult (RPKM 22.2) and 28 other tissues See more
Orthologs
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Genomic context

See Kansl1 in Genome Data Viewer
Location:
11; 11 E1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (104224327..104360584, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (104333501..104469508, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53648 Neighboring gene microtubule-associated protein tau Neighboring gene predicted gene, 22743 Neighboring gene cell division cycle 27 Neighboring gene myosin, light polypeptide 4 Neighboring gene predicted gene 11665

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1267, MGC90742

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone acetyltransferase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
KAT8 regulatory NSL complex subunit 1
Names
NSL complex protein NSL1
non-specific lethal 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081045.2NP_001074514.1  KAT8 regulatory NSL complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_001074514.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL593843, BC054752, BC079594
    Consensus CDS
    CCDS48953.1
    UniProtKB/Swiss-Prot
    Q80TG1, Q9D9G0
    Related
    ENSMUSP00000102590.2, ENSMUST00000106977.8
    Conserved Domains (1) summary
    pfam15275
    Location:816934
    PEHE; PEHE domain
  2. NM_001359634.1NP_001346563.1  KAT8 regulatory NSL complex subunit 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC054752, BC079594
    Consensus CDS
    CCDS48953.1
    UniProtKB/Swiss-Prot
    Q9D9G0
    Related
    ENSMUSP00000018556.5, ENSMUST00000018556.11
    Conserved Domains (1) summary
    pfam15275
    Location:816934
    PEHE; PEHE domain
  3. NM_001372458.1NP_001359387.1  KAT8 regulatory NSL complex subunit 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL593843, AL603709
    Conserved Domains (1) summary
    pfam15275
    Location:846964
    PEHE; PEHE domain
  4. NM_001372459.1NP_001359388.1  KAT8 regulatory NSL complex subunit 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL593843
    Consensus CDS
    CCDS88268.1
    UniProtKB/TrEMBL
    A2A5Y4
    Related
    ENSMUSP00000102585.2, ENSMUST00000106972.8
    Conserved Domains (1) summary
    pfam15275
    Location:879997
    PEHE; PEHE domain
  5. NM_001372460.1NP_001359389.1  KAT8 regulatory NSL complex subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL593843
    Conserved Domains (1) summary
    pfam15275
    Location:783901
    PEHE; PEHE domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    104224327..104360584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157074.1XP_036012967.1  KAT8 regulatory NSL complex subunit 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9D9G0
    Conserved Domains (1) summary
    pfam15275
    Location:816934
    PEHE; PEHE domain
  2. XM_006534447.5XP_006534510.1  KAT8 regulatory NSL complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006534510.1

    UniProtKB/TrEMBL
    A2A5Y4
    Related
    ENSMUSP00000102584.2, ENSMUST00000106971.2
    Conserved Domains (1) summary
    pfam15275
    Location:879997
    PEHE; PEHE domain
  3. XM_036157073.1XP_036012966.1  KAT8 regulatory NSL complex subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam15275
    Location:846964
    PEHE; PEHE domain
  4. XM_036157070.1XP_036012963.1  KAT8 regulatory NSL complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A2A5Y4
    Conserved Domains (1) summary
    pfam15275
    Location:879997
    PEHE; PEHE domain
  5. XM_036157071.1XP_036012964.1  KAT8 regulatory NSL complex subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam15275
    Location:846964
    PEHE; PEHE domain
  6. XM_006534446.5XP_006534509.1  KAT8 regulatory NSL complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006534509.1

    UniProtKB/TrEMBL
    A2A5Y4
    Conserved Domains (1) summary
    pfam15275
    Location:879997
    PEHE; PEHE domain
  7. XM_011249307.4XP_011247609.1  KAT8 regulatory NSL complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_011247609.1

    UniProtKB/TrEMBL
    A2A5Y4
    Conserved Domains (1) summary
    pfam15275
    Location:879997
    PEHE; PEHE domain
  8. XM_036157072.1XP_036012965.1  KAT8 regulatory NSL complex subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam15275
    Location:846964
    PEHE; PEHE domain
  9. XM_006534450.5XP_006534513.1  KAT8 regulatory NSL complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006534513.1

    UniProtKB/TrEMBL
    A2A5Y4
    Conserved Domains (1) summary
    pfam15275
    Location:879997
    PEHE; PEHE domain
  10. XM_030246421.1XP_030102281.1  KAT8 regulatory NSL complex subunit 1 isoform X2

    Conserved Domains (1) summary
    pfam15275
    Location:846964
    PEHE; PEHE domain
  11. XM_006534451.5XP_006534514.1  KAT8 regulatory NSL complex subunit 1 isoform X2

    See identical proteins and their annotated locations for XP_006534514.1

    Conserved Domains (1) summary
    pfam15275
    Location:846964
    PEHE; PEHE domain
  12. XM_006534449.5XP_006534512.1  KAT8 regulatory NSL complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006534512.1

    UniProtKB/TrEMBL
    A2A5Y4
    Conserved Domains (1) summary
    pfam15275
    Location:879997
    PEHE; PEHE domain
  13. XM_036157075.1XP_036012968.1  KAT8 regulatory NSL complex subunit 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9D9G0
    Conserved Domains (1) summary
    pfam15275
    Location:816934
    PEHE; PEHE domain
  14. XM_036157077.1XP_036012970.1  KAT8 regulatory NSL complex subunit 1 isoform X4

    Conserved Domains (1) summary
    pfam15275
    Location:783901
    PEHE; PEHE domain
  15. XM_036157076.1XP_036012969.1  KAT8 regulatory NSL complex subunit 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9D9G0
    Conserved Domains (1) summary
    pfam15275
    Location:816934
    PEHE; PEHE domain
  16. XM_036157078.1XP_036012971.1  KAT8 regulatory NSL complex subunit 1 isoform X4

    Conserved Domains (1) summary
    pfam15275
    Location:783901
    PEHE; PEHE domain