U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Snx7 sorting nexin 7 [ Mus musculus (house mouse) ]

Gene ID: 76561, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Snx7provided by MGI
Official Full Name
sorting nexin 7provided by MGI
Primary source
MGI:MGI:1923811
See related
Ensembl:ENSMUSG00000028007 AllianceGenome:MGI:1923811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510028H01Rik
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including endocytic recycling; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in early endosome membrane. Predicted to be active in early endosome and phagophore assembly site. Orthologous to human SNX7 (sorting nexin 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 19.9), duodenum adult (RPKM 18.6) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Snx7 in Genome Data Viewer
Location:
3 G1; 3 51.21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (117575146..117662585, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (117781497..117868936, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08804 Neighboring gene phospholipid phosphatase related 4 Neighboring gene phospholipid phosphatase related 5 Neighboring gene STARR-seq mESC enhancer starr_08806 Neighboring gene STARR-seq mESC enhancer starr_08807 Neighboring gene STARR-seq mESC enhancer starr_08808 Neighboring gene STARR-seq mESC enhancer starr_08809 Neighboring gene STARR-seq mESC enhancer starr_08810 Neighboring gene predicted gene, 52614 Neighboring gene predicted gene, 32344 Neighboring gene STARR-seq mESC enhancer starr_08811 Neighboring gene STARR-seq mESC enhancer starr_08812 Neighboring gene STARR-seq mESC enhancer starr_08813 Neighboring gene STARR-seq mESC enhancer starr_08815 Neighboring gene predicted gene, 26871 Neighboring gene microRNA 137

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. EFA6A, a guanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth. Fukaya M, et al. J Neurochem, 2014 Apr. PMID 24261326
  2. TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. Ragancokova D, et al. J Clin Invest, 2014 Mar. PMID 24487590, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC107328

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sorting nexin-7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190156.1 → NP_001177085.1  sorting nexin-7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC115029, AC115933, AK038971, AK052487
    UniProtKB/TrEMBL
    F6RSR4
    Related
    ENSMUSP00000128007.2, ENSMUST00000169812.8
    Conserved Domains (2) summary
    cd07284
    Location:90 → 205
    PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
    cl12013
    Location:189 → 380
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_029655.3 → NP_083931.2  sorting nexin-7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK038971, AK052487
    Consensus CDS
    CCDS38615.2
    UniProtKB/Swiss-Prot
    Q9CY18
    UniProtKB/TrEMBL
    F8WI30, Q5M8N3
    Related
    ENSMUSP00000029639.6, ENSMUST00000029639.12
    Conserved Domains (2) summary
    cd07284
    Location:90 → 205
    PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
    cd07666
    Location:189 → 431
    BAR_SNX7; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    117575146..117662585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY18.1 GenPept UniProtKB/Swiss-Prot:Q9CY18

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools