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Snx7 sorting nexin 7 [ Mus musculus (house mouse) ]

Gene ID: 76561, updated on 5-Mar-2024

Summary

Official Symbol
Snx7provided by MGI
Official Full Name
sorting nexin 7provided by MGI
Primary source
MGI:MGI:1923811
See related
Ensembl:ENSMUSG00000028007 AllianceGenome:MGI:1923811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510028H01Rik
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in cytoplasmic vesicle and membrane. Orthologous to human SNX7 (sorting nexin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 19.9), duodenum adult (RPKM 18.6) and 26 other tissues See more
Orthologs
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Genomic context

See Snx7 in Genome Data Viewer
Location:
3 G1; 3 51.21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (117575146..117662585, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (117781497..117868936, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08804 Neighboring gene phospholipid phosphatase related 4 Neighboring gene phospholipid phosphatase related 5 Neighboring gene STARR-seq mESC enhancer starr_08806 Neighboring gene STARR-seq mESC enhancer starr_08807 Neighboring gene STARR-seq mESC enhancer starr_08808 Neighboring gene STARR-seq mESC enhancer starr_08809 Neighboring gene STARR-seq mESC enhancer starr_08810 Neighboring gene predicted gene, 52614 Neighboring gene predicted gene, 32344 Neighboring gene STARR-seq mESC enhancer starr_08811 Neighboring gene STARR-seq mESC enhancer starr_08812 Neighboring gene STARR-seq mESC enhancer starr_08813 Neighboring gene STARR-seq mESC enhancer starr_08815 Neighboring gene predicted gene, 26871 Neighboring gene microRNA 137

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107328

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190156.1NP_001177085.1  sorting nexin-7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC115029, AC115933, AK038971, AK052487
    UniProtKB/TrEMBL
    F6RSR4
    Related
    ENSMUSP00000128007.2, ENSMUST00000169812.8
    Conserved Domains (2) summary
    cd07284
    Location:90205
    PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
    cl12013
    Location:189380
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_029655.3NP_083931.2  sorting nexin-7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK038971, AK052487
    Consensus CDS
    CCDS38615.2
    UniProtKB/Swiss-Prot
    Q9CY18
    UniProtKB/TrEMBL
    F8WI30, Q5M8N3
    Related
    ENSMUSP00000029639.6, ENSMUST00000029639.12
    Conserved Domains (2) summary
    cd07284
    Location:90205
    PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
    cd07666
    Location:189431
    BAR_SNX7; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    117575146..117662585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)