Rmc1 regulator of MON1-CCZ1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rmc1provided by MGI
Official Full Name: regulator of MON1-CCZ1provided by MGI
Primary source: MGI:MGI:1916528
See related: Ensembl:ENSMUSG00000024410 AllianceGenome:MGI:1916528
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mic1; Mic-1; Wdr98; 2400010D15Rik; 3110002H16Rik
Summary: Predicted to be involved in regulation of autophagy. Predicted to act upstream of or within autophagy. Predicted to be located in endosome; lysosome; and membrane. Predicted to be part of Mon1-Ccz1 complex. Predicted to be active in late endosome membrane. Is expressed in several structures, including adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human RMC1 (regulator of MON1-CCZ1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14.5 (RPKM 20.0), liver E14 (RPKM 18.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18; 18 A1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (12301746..12331732)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (12168689..12198675)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Ertd723e (e-PCR), detects polymorphism
- UniSTS:167242

RH136258 (e-PCR)
- UniSTS:210251

C85354 (e-PCR)
- UniSTS:160712

RH126057 (e-PCR)
- UniSTS:162769

Homology

Homologs of the Rmc1 gene: The Rmc1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 492 organisms have orthologs with human gene Rmc1
Orthologs

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Mon1-Ccz1 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of Mon1-Ccz1 complex	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regulator of MON1-CCZ1 complex

Names: colon cancer-associated protein Mic1 homolog; uncharacterized protein C18orf8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029623.2 → NP_083899.1 regulator of MON1-CCZ1 complex

See identical proteins and their annotated locations for NP_083899.1

Status: VALIDATED

Source sequence(s)

AF003352, AK144623, AK159691

Consensus CDS

CCDS29063.1

UniProtKB/Swiss-Prot

O35606, Q8VC42

UniProtKB/TrEMBL

A0A8C6H577, Q3TWH4, Q3U4H5, Q3UMX3

Related

ENSMUSP00000025276.9, ENSMUST00000025276.15

Conserved Domains (1) summary

pfam07035
Location:475 → 631

Mic1; Colon cancer-associated protein Mic1-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

12301746..12331732

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526341.3 → XP_006526404.1 regulator of MON1-CCZ1 complex isoform X1

Conserved Domains (1) summary

pfam07035
Location:475 → 632

Mic1; Colon cancer-associated protein Mic1-like
XM_006526342.5 → XP_006526405.1 regulator of MON1-CCZ1 complex isoform X2

Conserved Domains (1) summary

pfam07035
Location:421 → 578

Mic1; Colon cancer-associated protein Mic1-like