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Fbxo31 F-box protein 31 [ Mus musculus (house mouse) ]

Gene ID: 76454, updated on 17-Aug-2024

Summary

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Official Symbol
Fbxo31provided by MGI
Official Full Name
F-box protein 31provided by MGI
Primary source
MGI:MGI:1354708
See related
Ensembl:ENSMUSG00000052934 AllianceGenome:MGI:1354708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbx14; Fbxo14; 1110003O08Rik; 2310046N15Rik
Summary
Predicted to enable cyclin binding activity. Predicted to be involved in several processes, including mitotic G1 DNA damage checkpoint signaling; positive regulation of dendrite morphogenesis; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in neuronal cell body. Is expressed in several structures, including adrenal gland; brain; early embryo; genitourinary system; and gut gland. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human FBXO31 (F-box protein 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 24.3), cortex adult (RPKM 21.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 70.65 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122276182..122305607, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121549443..121578864, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700018B08 gene Neighboring gene RIKEN cDNA 1700030M09 gene Neighboring gene STARR-positive B cell enhancer ABC_E2276 Neighboring gene nuclear encoded tRNA methionine 17 (anticodon CAT) Neighboring gene predicted gene, 17786

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Truncation of the E3 ubiquitin ligase component FBXO31 causes non-syndromic autosomal recessive intellectual disability in a Pakistani family. Mir A, et al. Hum Genet, 2014 Aug. PMID 24623383
  2. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
  3. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
  4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency.
    Title: Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
F-box only protein 31
Names
F-box only protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414923.1 → NP_001401852.1  F-box only protein 31 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122205, AC182458

  2. NM_001414924.1 → NP_001401853.1  F-box only protein 31 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122205, AC182458

  3. NM_001414925.1 → NP_001401854.1  F-box only protein 31 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122205, AC182458

  4. NM_133765.5 → NP_598526.3  F-box only protein 31 isoform 1

    See identical proteins and their annotated locations for NP_598526.3

    Status: VALIDATED

    Source sequence(s)
    AC122205, AC182458
    Consensus CDS
    CCDS52693.1
    UniProtKB/Swiss-Prot
    Q3TQF0, Q8K1A7, Q9JJC4
    Related
    ENSMUSP00000057573.6, ENSMUST00000059018.14
    Conserved Domains (2) summary
    pfam12014
    Location:271 → 329
    DUF3506; Domain of unknown function (DUF3506)
    pfam12937
    Location:61 → 99
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    122276182..122305607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004934896.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TQF0.1 GenPept UniProtKB/Swiss-Prot:Q3TQF0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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