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Trp53rkb transformation related protein 53 regulating kinase B [ Mus musculus (house mouse) ]

Gene ID: 76367, updated on 13-Oct-2022

Summary

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Official Symbol
Trp53rkbprovided by MGI
Official Full Name
transformation related protein 53 regulating kinase Bprovided by MGI
Primary source
MGI:MGI:1914050
See related
Ensembl:ENSMUSG00000042854 AllianceGenome:MGI:1914050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRPK; Nori-2; Tp53rk; Tp53rkb; Trp53rk; Trp53tk; mNori-2p; 2810408M09Rik; 4933401B08Rik; 5630401H01Rik
Summary
Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in nucleus. Is expressed in central nervous system; forelimb bud; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 4.3), CNS E11.5 (RPKM 2.8) and 28 other tissues See more
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Genomic context

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See Trp53rkb in Genome Data Viewer
Location:
2; 2 H3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166634379..166641412)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166792459..166799492)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46777 Neighboring gene predicted gene, 31117 Neighboring gene ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) Neighboring gene predicted gene, 31204 Neighboring gene chromosome segregation 1-like (S. cerevisiae)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. Abe Y, et al. J Biol Chem, 2001 Nov 23. PMID 11546806
  2. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Braun DA, et al. Nat Genet, 2017 Oct. PMID 28805828, Free PMC Article
  3. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Homologs of the Trp53rkb gene: The Trp53rkb gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Clone Names

  • MGC2882

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
part_of EKC/KEOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of EKC/KEOPS complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
EKC/KEOPS complex subunit Tp53rkb; EKC/KEOPS complex subunit Tp53rk
Names
TP53-regulating kinase
Trp53 regulating kinase
atypical serine/threonine protein kinase Tp53rk
p53-related protein kinase
NP_076304.2
XP_006500434.1
XP_030108048.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023815.5 → NP_076304.2  EKC/KEOPS complex subunit Tp53rkb

    See identical proteins and their annotated locations for NP_076304.2

    Status: VALIDATED

    Source sequence(s)
    AL591703
    Consensus CDS
    CCDS17090.1
    UniProtKB/TrEMBL
    Q543M9
    Related
    ENSMUSP00000115353.2, ENSMUST00000151826.2
    Conserved Domains (1) summary
    COG3642
    Location:27 → 244
    Bud32; tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    166634379..166641412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500371.4 → XP_006500434.1  EKC/KEOPS complex subunit Tp53rk isoform X1

    Conserved Domains (1) summary
    COG3642
    Location:51 → 268
    Bud32; tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]

  2. XM_030252188.2 → XP_030108048.1  EKC/KEOPS complex subunit Tp53rk isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 141
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PW4.1 GenPept UniProtKB/Swiss-Prot:Q99PW4

Gene LinkOut

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