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Cog2 component of oligomeric golgi complex 2 [ Mus musculus (house mouse) ]

Gene ID: 76332, updated on 2-Nov-2024

Summary

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Official Symbol
Cog2provided by MGI
Official Full Name
component of oligomeric golgi complex 2provided by MGI
Primary source
MGI:MGI:1923582
See related
Ensembl:ENSMUSG00000031979 AllianceGenome:MGI:1923582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ldlc; 1190002B08Rik; 2700012E02Rik
Summary
Predicted to be involved in Golgi organization; glycosylation; and retrograde transport, vesicle recycling within Golgi. Predicted to be located in Golgi stack. Predicted to be part of Golgi transport complex. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIq. Orthologous to human COG2 (component of oligomeric golgi complex 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 11.2), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cog2 in Genome Data Viewer
Location:
8 E2; 8 72.78 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125247506..125278747)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124520767..124552008)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30209 Neighboring gene STARR-seq mESC enhancer starr_23007 Neighboring gene predicted gene, 39280 Neighboring gene STARR-positive B cell enhancer ABC_E9122 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:127097574-127097727 Neighboring gene angiotensinogen Neighboring gene STARR-seq mESC enhancer starr_23008 Neighboring gene calpain 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures. Kim S, et al. Biol Psychiatry, 2009 Mar 1. PMID 18986647, Free PMC Article
  2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, vesicle recycling within Golgi IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, vesicle recycling within Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Golgi transport complex IEA
Inferred from Electronic Annotation
more info
  
part_of Golgi transport complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
conserved oligomeric Golgi complex subunit 2
Names
COG complex subunit 2
low density lipoprotein receptor defect C complementing
low density lipoprotein receptor defect C-complementing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029746.3 → NP_084022.2  conserved oligomeric Golgi complex subunit 2

    See identical proteins and their annotated locations for NP_084022.2

    Status: VALIDATED

    Source sequence(s)
    AC126930, AI837595, AK004441, AK012236, CJ093818, CO423795, CX205121, W74920
    Consensus CDS
    CCDS22771.1
    UniProtKB/Swiss-Prot
    Q3TF44, Q921L5, Q9CSQ1
    UniProtKB/TrEMBL
    Q3TAN4
    Related
    ENSMUSP00000034460.5, ENSMUST00000034460.11
    Conserved Domains (2) summary
    pfam06148
    Location:15 → 147
    COG2; COG (conserved oligomeric Golgi) complex component, COG2
    pfam12022
    Location:566 → 692
    DUF3510; Domain of unknown function (DUF3510)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    125247506..125278747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001778485.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921L5.2 GenPept UniProtKB/Swiss-Prot:Q921L5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
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