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Rab30 RAB30, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 75985, updated on 18-Sep-2024

Summary

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Official Symbol
Rab30provided by MGI
Official Full Name
RAB30, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1923235
See related
Ensembl:ENSMUSG00000030643 AllianceGenome:MGI:1923235
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsb30; 5033421K01Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in Golgi organization. Predicted to be located in Golgi cisterna and cis-Golgi network. Predicted to be active in trans-Golgi network. Is expressed in cranial ganglion; hindbrain; and ventral grey horn. Orthologous to human RAB30 (RAB30, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 3.5), CNS E18 (RPKM 2.7) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Rab30 in Genome Data Viewer
Location:
7 E1; 7 51.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (92390845..92493743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (92741637..92844535)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2551 Neighboring gene RIKEN cDNA 4632427E13 gene Neighboring gene STARR-seq mESC enhancer starr_19530 Neighboring gene STARR-positive B cell enhancer ABC_E8184 Neighboring gene STARR-seq mESC enhancer starr_19531 Neighboring gene STARR-positive B cell enhancer ABC_E9697 Neighboring gene STARR-seq mESC enhancer starr_19532 Neighboring gene DNA damage-induced apoptosis suppressor Neighboring gene predicted gene, 40448 Neighboring gene prolylcarboxypeptidase (angiotensinase C)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression profiling of Rab GTPases reveals the involvement of Rab20 and Rab32 in acute brain inflammation in mice. Liang Y, et al. Neurosci Lett, 2012 Oct 11. PMID 22960262
  2. Elevation and characteristics of Rab30 and S100a8/S100a9 expression in an early phase of liver regeneration in the mouse. Chiba M, et al. Int J Mol Med, 2011 Apr. PMID 21308349
  3. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727
  4. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082
  5. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12578829

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab30 facilitates lipid homeostasis during fasting.
    Title: Rab30 facilitates lipid homeostasis during fasting.
  2. Rabs may participate in inflammatory response in microglia during brain inflammation.
    Title: Expression profiling of Rab GTPases reveals the involvement of Rab20 and Rab32 in acute brain inflammation in mice.
  3. Rab30 and S100a8/S100a9 were indicated to play roles in the initiation of liver regeneration as well as possibly in the functional switch of the liver in the newborn stage.
    Title: Elevation and characteristics of Rab30 and S100a8/S100a9 expression in an early phase of liver regeneration in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ras-related protein Rab-30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029494.2 → NP_083770.2  ras-related protein Rab-30

    See identical proteins and their annotated locations for NP_083770.2

    Status: PROVISIONAL

    Source sequence(s)
    BC017550
    Consensus CDS
    CCDS21450.1
    UniProtKB/Swiss-Prot
    Q3UQR3, Q923S9, Q9D3Q6
    UniProtKB/TrEMBL
    Q0PD24
    Related
    ENSMUSP00000032879.8, ENSMUST00000032879.15
    Conserved Domains (1) summary
    cd04114
    Location:3 → 171
    Rab30; Rab GTPase family 30 (Rab30)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    92390845..92493743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508294.3 → XP_006508357.1  ras-related protein Rab-30 isoform X1

    See identical proteins and their annotated locations for XP_006508357.1

    UniProtKB/Swiss-Prot
    Q3UQR3, Q923S9, Q9D3Q6
    UniProtKB/TrEMBL
    Q0PD24
    Conserved Domains (1) summary
    cd04114
    Location:3 → 171
    Rab30; Rab GTPase family 30 (Rab30)

  2. XM_030243075.2 → XP_030098935.1  ras-related protein Rab-30 isoform X1

    UniProtKB/Swiss-Prot
    Q3UQR3, Q923S9, Q9D3Q6
    UniProtKB/TrEMBL
    Q0PD24
    Conserved Domains (1) summary
    cd04114
    Location:3 → 171
    Rab30; Rab GTPase family 30 (Rab30)

  3. XM_006508293.5 → XP_006508356.1  ras-related protein Rab-30 isoform X1

    See identical proteins and their annotated locations for XP_006508356.1

    UniProtKB/Swiss-Prot
    Q3UQR3, Q923S9, Q9D3Q6
    UniProtKB/TrEMBL
    Q0PD24
    Conserved Domains (1) summary
    cd04114
    Location:3 → 171
    Rab30; Rab GTPase family 30 (Rab30)

  4. XM_030243074.2 → XP_030098934.1  ras-related protein Rab-30 isoform X1

    UniProtKB/Swiss-Prot
    Q3UQR3, Q923S9, Q9D3Q6
    UniProtKB/TrEMBL
    Q0PD24
    Related
    ENSMUSP00000102798.2, ENSMUST00000107180.8
    Conserved Domains (1) summary
    cd04114
    Location:3 → 171
    Rab30; Rab GTPase family 30 (Rab30)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923S9.1 GenPept UniProtKB/Swiss-Prot:Q923S9

Gene LinkOut

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