Dcp1a decapping mRNA 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcp1aprovided by MGI
Official Full Name: decapping mRNA 1Aprovided by MGI
Primary source: MGI:MGI:1923151
See related: Ensembl:ENSMUSG00000021962 AllianceGenome:MGI:1923151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SMIF; Mitc1; D14Ertd817e; 1110066A22Rik; 4930568L04Rik
Summary: Predicted to enable identical protein binding activity; kinesin binding activity; and mRNA binding activity. Predicted to be involved in deadenylation-dependent decapping of nuclear-transcribed mRNA; deadenylation-independent decapping of nuclear-transcribed mRNA; and protein localization to cytoplasmic stress granule. Predicted to act upstream of or within positive regulation of transcription, DNA-templated and transforming growth factor beta receptor signaling pathway. Located in P-body. Is expressed in several structures, including genitourinary system; limb; liver; muscle tissue; and spleen. Orthologous to human DCP1A (decapping mRNA 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 10.4), limb E14.5 (RPKM 9.9) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 14 B; 14 18.75 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (30201443..30249013)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (30479486..30527056)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation.
Title: mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation.
mRNA decapping factor Dcp1a is essential for embryonic growth in mice.
Title: mRNA decapping factor Dcp1a is essential for embryonic growth in mice.
PKR-induced translational inhibition appears to be specific to Dcp1a because the expression of other P-body components, Pan2, Pan3, Ccr4, or Caf1, did not result in the inhibition of poliovirus gene expression or induce eIF2alpha phosphorylation.
Title: mRNA decapping enzyme 1a (Dcp1a)-induced translational arrest through protein kinase R (PKR) activation requires the N-terminal enabled vasodilator-stimulated protein homology 1 (EVH1) domain.
ERK-phosphorylated Dcp1a enhances its interaction with the decapping enzyme Dcp2 during early differentiation of 3T3-L1 cells.
Title: Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes.
Recruitment of DCP1A and DCP2 increases the mRNA degradation capacity of the maturing oocyte so that by the 2-cell stage, most of the maternal mRNA is degraded.
Title: Losing mom's message: requirement for DCP1A and DCP2 in the degradation of maternal transcripts during oocyte maturation.
The results showed that DCP1A and DCP2 are critical in the transition from mRNA stability to instability during meiotic maturation and that mRNA degradation must be successful to execute the oocyte-to-zygote transition.
Title: Maternally recruited DCP1A and DCP2 contribute to messenger RNA degradation during oocyte maturation and genome activation in mouse.
Data show the presence of P-body-like foci in mouse oocytes, as revealed by the presence of Dcp1a and the colocalization of RNA-associated protein 55 (RAP55) and the DEAD box RNA helicase Rck/p54.
Title: Dcp1-bodies in mouse oocytes.
These findings suggest a novel post-translational modification that may influence the function of Dcp1a in response to various physiological cues.
Title: Dcp1a phosphorylation along neuronal development and stress.
Overexpression of wild-type SMIF enhanced expression of TGFbeta/BMP regulated genes, whereas a dominant-negative SMIF mutant suppressed expression.
Title: SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:237148

AW530962 (e-PCR)
- UniSTS:244577

RH136288 (e-PCR)
- UniSTS:210281

RH126634 (e-PCR)
- UniSTS:209009

D14Ertd817e (e-PCR), detects polymorphism
- UniSTS:167150

Homology

Homologs of the Dcp1a gene: The Dcp1a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 475 organisms have orthologs with human gene Dcp1a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transcription factor binding	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in methylguanosine-cap decapping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISA Inferred from Sequence Alignment more info	PubMed
involved_in positive regulation of catalytic activity	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISA Inferred from Sequence Alignment more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: mRNA-decapping enzyme 1A

Names: DCP1 decapping enzyme homolog A; MAD homolog 4 interacting transcription coactivator 1; Smad4-interacting transcriptional co-activator; decapping enzyme; transcription factor SMIF

XP_006519718.1

EC 3.6.1.62

XP_006519719.1

EC 3.6.1.62

XP_036014784.1

EC 3.6.1.62

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411755.1 → NP_001398684.1 mRNA-decapping enzyme 1A isoform 2

Status: VALIDATED

Source sequence(s)

AC119886
NM_001411756.1 → NP_001398685.1 mRNA-decapping enzyme 1A isoform 3

Status: VALIDATED

Source sequence(s)

AC119886
NM_001411757.1 → NP_001398686.1 mRNA-decapping enzyme 1A isoform 4

Status: VALIDATED

Source sequence(s)

AC119886
NM_133761.4 → NP_598522.4 mRNA-decapping enzyme 1A isoform 1

Status: VALIDATED

Source sequence(s)

AC119886

Consensus CDS

CCDS36848.1

Related

ENSMUSP00000022535.8, ENSMUST00000022535.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

30201443..30249013

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519656.3 → XP_006519719.1 mRNA-decapping enzyme 1A isoform X2

Conserved Domains (2) summary

cd09804
Location:26 → 146

Dcp1; mRNA decapping enzyme 1 (Dcp1)

pfam16741
Location:521 → 563

mRNA_decap_C; mRNA-decapping enzyme C-terminus
XM_006519655.5 → XP_006519718.1 mRNA-decapping enzyme 1A isoform X1

Conserved Domains (3) summary

cd09804
Location:26 → 146

Dcp1; mRNA decapping enzyme 1 (Dcp1)

pfam16014
Location:308 → 456

SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

pfam16741
Location:537 → 579

mRNA_decap_C; mRNA-decapping enzyme C-terminus
XM_036158891.1 → XP_036014784.1 mRNA-decapping enzyme 1A isoform X3

Conserved Domains (3) summary

cd09804
Location:26 → 146

Dcp1; mRNA decapping enzyme 1 (Dcp1)

PHA03247
Location:293 → 508

PHA03247; large tegument protein UL36; Provisional

pfam16741
Location:499 → 541

mRNA_decap_C; mRNA-decapping enzyme C-terminus