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Dcp1a decapping mRNA 1A [ Mus musculus (house mouse) ]

Gene ID: 75901, updated on 8-Dec-2022

Summary

Official Symbol
Dcp1aprovided by MGI
Official Full Name
decapping mRNA 1Aprovided by MGI
Primary source
MGI:MGI:1923151
See related
Ensembl:ENSMUSG00000021962 AllianceGenome:MGI:1923151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SMIF; Mitc1; D14Ertd817e; 1110066A22Rik; 4930568L04Rik
Summary
Predicted to enable identical protein binding activity; kinesin binding activity; and mRNA binding activity. Predicted to be involved in deadenylation-dependent decapping of nuclear-transcribed mRNA; deadenylation-independent decapping of nuclear-transcribed mRNA; and protein localization to cytoplasmic stress granule. Predicted to act upstream of or within positive regulation of transcription, DNA-templated and transforming growth factor beta receptor signaling pathway. Located in P-body. Is expressed in several structures, including genitourinary system; limb; liver; muscle tissue; and spleen. Orthologous to human DCP1A (decapping mRNA 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 10.4), limb E14.5 (RPKM 9.9) and 28 other tissues See more
Orthologs
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Genomic context

See Dcp1a in Genome Data Viewer
Location:
14 B; 14 18.75 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30201443..30249013)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30479486..30527056)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1D subunit Neighboring gene RIKEN cDNA 4831407H17 gene Neighboring gene microtubule-associated protein 1S pseudogene Neighboring gene predicted gene, 35566 Neighboring gene microRNA 3076 Neighboring gene transketolase Neighboring gene predicted gene, 52147 Neighboring gene protein kinase C, delta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription factor binding ISA
Inferred from Sequence Alignment
more info
PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex ISA
Inferred from Sequence Alignment
more info
PubMed 

General protein information

Preferred Names
mRNA-decapping enzyme 1A
Names
DCP1 decapping enzyme homolog A
MAD homolog 4 interacting transcription coactivator 1
Smad4-interacting transcriptional co-activator
decapping enzyme
transcription factor SMIF
XP_006519718.1
XP_006519719.1
XP_036014784.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411755.1NP_001398684.1  mRNA-decapping enzyme 1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119886
  2. NM_001411756.1NP_001398685.1  mRNA-decapping enzyme 1A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119886
  3. NM_001411757.1NP_001398686.1  mRNA-decapping enzyme 1A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC119886
  4. NM_133761.4NP_598522.4  mRNA-decapping enzyme 1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC119886
    Consensus CDS
    CCDS36848.1
    Related
    ENSMUSP00000022535.8, ENSMUST00000022535.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30201443..30249013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519656.3XP_006519719.1  mRNA-decapping enzyme 1A isoform X2

    Conserved Domains (2) summary
    cd09804
    Location:26146
    Dcp1; mRNA decapping enzyme 1 (Dcp1)
    pfam16741
    Location:521563
    mRNA_decap_C; mRNA-decapping enzyme C-terminus
  2. XM_006519655.5XP_006519718.1  mRNA-decapping enzyme 1A isoform X1

    Conserved Domains (3) summary
    cd09804
    Location:26146
    Dcp1; mRNA decapping enzyme 1 (Dcp1)
    pfam16014
    Location:308456
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
    pfam16741
    Location:537579
    mRNA_decap_C; mRNA-decapping enzyme C-terminus
  3. XM_036158891.1XP_036014784.1  mRNA-decapping enzyme 1A isoform X3

    Conserved Domains (3) summary
    cd09804
    Location:26146
    Dcp1; mRNA decapping enzyme 1 (Dcp1)
    PHA03247
    Location:293508
    PHA03247; large tegument protein UL36; Provisional
    pfam16741
    Location:499541
    mRNA_decap_C; mRNA-decapping enzyme C-terminus