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Smurf1 SMAD specific E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 75788, updated on 27-Feb-2024

Summary

Official Symbol
Smurf1provided by MGI
Official Full Name
SMAD specific E3 ubiquitin protein ligase 1provided by MGI
Primary source
MGI:MGI:1923038
See related
Ensembl:ENSMUSG00000038780 AllianceGenome:MGI:1923038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1625; 4930431E10Rik
Summary
Predicted to enable I-SMAD binding activity; R-SMAD binding activity; and ubiquitin protein ligase activity. Involved in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization. Acts upstream of or within negative regulation of ossification and protein ubiquitination. Predicted to be located in axon; neuronal cell body; and plasma membrane. Predicted to be active in cytoplasm. Predicted to colocalize with mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 16.3), ovary adult (RPKM 16.0) and 28 other tissues See more
Orthologs
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Genomic context

See Smurf1 in Genome Data Viewer
Location:
5 G2; 5 84.83 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144813305..144902657, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144876495..144965899, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14819 Neighboring gene predicted gene, 38739 Neighboring gene predicted gene, 23995 Neighboring gene transformation/transcription domain-associated protein Neighboring gene microRNA 7039 Neighboring gene predicted gene, 33821 Neighboring gene STARR-positive B cell enhancer ABC_E10365 Neighboring gene karyopherin subunit alpha 7 Neighboring gene predicted gene, 33904 Neighboring gene predicted gene 4871

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables activin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in engulfment of target by autophagosome ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to vacuole involved in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate localization to autophagosome ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SMURF1
Names
HECT-type E3 ubiquitin transferase SMURF1
Smad ubiquitination regulatory factor 1
NP_001033716.1
NP_083714.3
XP_006504947.1
XP_011239318.1
XP_011239319.1
XP_036021480.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038627.1NP_001033716.1  E3 ubiquitin-protein ligase SMURF1 isoform 1

    See identical proteins and their annotated locations for NP_001033716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC113295, AK015264, AK034736, CB524571, CX568994
    Consensus CDS
    CCDS39380.1
    UniProtKB/Swiss-Prot
    Q3U412, Q8K300, Q9CUN6
    Related
    ENSMUSP00000082827.5, ENSMUST00000085684.11
    Conserved Domains (4) summary
    cd08382
    Location:14138
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:281313
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:397728
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:373728
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  2. NM_029438.3NP_083714.3  E3 ubiquitin-protein ligase SMURF1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AC113295, AK015264, CB524571, CX568994
    Consensus CDS
    CCDS39381.1
    UniProtKB/TrEMBL
    E9Q4K9
    Related
    ENSMUSP00000098029.3, ENSMUST00000100461.7
    Conserved Domains (4) summary
    cd08382
    Location:14138
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:281313
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:397725
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:373725
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    144813305..144902657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165587.1XP_036021480.1  E3 ubiquitin-protein ligase SMURF1 isoform X3

    Conserved Domains (3) summary
    cd08382
    Location:14128
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:285317
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:377732
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  2. XM_011241017.3XP_011239319.1  E3 ubiquitin-protein ligase SMURF1 isoform X4

    Conserved Domains (3) summary
    cd08382
    Location:14138
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:236267
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:324679
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  3. XM_011241016.3XP_011239318.1  E3 ubiquitin-protein ligase SMURF1 isoform X2

    Conserved Domains (3) summary
    cd08382
    Location:14138
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:307339
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:399751
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  4. XM_006504884.3XP_006504947.1  E3 ubiquitin-protein ligase SMURF1 isoform X1

    UniProtKB/TrEMBL
    E9PYU8
    Related
    ENSMUSP00000106305.2, ENSMUST00000110677.8
    Conserved Domains (3) summary
    cd08382
    Location:14138
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:307339
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:399754
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...