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Vwa5b1 von Willebrand factor A domain containing 5B1 [ Mus musculus (house mouse) ]

Gene ID: 75718, updated on 2-Nov-2024

Summary

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Official Symbol
Vwa5b1provided by MGI
Official Full Name
von Willebrand factor A domain containing 5B1provided by MGI
Primary source
MGI:MGI:1922968
See related
Ensembl:ENSMUSG00000028753 AllianceGenome:MGI:1922968
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4931403E03Rik
Summary
Predicted to be located in extracellular region. Orthologous to human VWA5B1 (von Willebrand factor A domain containing 5B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 7.2) and CNS E18 (RPKM 0.4) See more
Orthologs
human all
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Genomic context

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See Vwa5b1 in Genome Data Viewer
Location:
4 D3; 4 70.43 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138291540..138363303, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138564229..138635992, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11806 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 1 Neighboring gene predicted gene, 32549 Neighboring gene STARR-seq mESC enhancer starr_11810 Neighboring gene predicted gene, 32662 Neighboring gene predicted gene, 32770 Neighboring gene STARR-seq mESC enhancer starr_11814 Neighboring gene UBX domain protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
von Willebrand factor A domain-containing protein 5B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029401.1 → NP_083677.1  von Willebrand factor A domain-containing protein 5B1 precursor

    See identical proteins and their annotated locations for NP_083677.1

    Status: PROVISIONAL

    Source sequence(s)
    BC132477
    Consensus CDS
    CCDS51336.1
    UniProtKB/Swiss-Prot
    A9Z1V5, Q6PFX4, Q9CUE8
    UniProtKB/TrEMBL
    B1AZ81
    Related
    ENSMUSP00000030533.6, ENSMUST00000030533.12
    Conserved Domains (2) summary
    cd01461
    Location:351 → 519
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:16 → 561
    marine_srt_targ; marine proteobacterial sortase target protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138291540..138363303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539245.4 → XP_006539308.1  von Willebrand factor A domain-containing protein 5B1 isoform X3

    Conserved Domains (2) summary
    cd01461
    Location:365 → 533
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:30 → 575
    marine_srt_targ; marine proteobacterial sortase target protein

  2. XM_006539241.4 → XP_006539304.1  von Willebrand factor A domain-containing protein 5B1 isoform X1

    Conserved Domains (2) summary
    cd01461
    Location:365 → 533
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:30 → 575
    marine_srt_targ; marine proteobacterial sortase target protein

  3. XM_036164524.1 → XP_036020417.1  von Willebrand factor A domain-containing protein 5B1 isoform X4

    Conserved Domains (2) summary
    cd01461
    Location:365 → 533
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    cl02699
    Location:16 → 93
    VIT; Vault protein inter-alpha-trypsin domain

  4. XM_017320433.2 → XP_017175922.1  von Willebrand factor A domain-containing protein 5B1 isoform X2

    UniProtKB/Swiss-Prot
    A9Z1V5, Q6PFX4, Q9CUE8
    UniProtKB/TrEMBL
    B1AZ81
    Conserved Domains (2) summary
    cd01461
    Location:351 → 519
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:16 → 561
    marine_srt_targ; marine proteobacterial sortase target protein

  5. XM_006539243.4 → XP_006539306.1  von Willebrand factor A domain-containing protein 5B1 isoform X2

    See identical proteins and their annotated locations for XP_006539306.1

    UniProtKB/Swiss-Prot
    A9Z1V5, Q6PFX4, Q9CUE8
    UniProtKB/TrEMBL
    B1AZ81
    Conserved Domains (2) summary
    cd01461
    Location:351 → 519
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:16 → 561
    marine_srt_targ; marine proteobacterial sortase target protein

  6. XM_006539244.2 → XP_006539307.1  von Willebrand factor A domain-containing protein 5B1 isoform X2

    See identical proteins and their annotated locations for XP_006539307.1

    UniProtKB/Swiss-Prot
    A9Z1V5, Q6PFX4, Q9CUE8
    UniProtKB/TrEMBL
    B1AZ81
    Conserved Domains (2) summary
    cd01461
    Location:351 → 519
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:16 → 561
    marine_srt_targ; marine proteobacterial sortase target protein

  7. XM_011250349.1 → XP_011248651.1  von Willebrand factor A domain-containing protein 5B1 isoform X2

    See identical proteins and their annotated locations for XP_011248651.1

    UniProtKB/Swiss-Prot
    A9Z1V5, Q6PFX4, Q9CUE8
    UniProtKB/TrEMBL
    B1AZ81
    Conserved Domains (2) summary
    cd01461
    Location:351 → 519
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:16 → 561
    marine_srt_targ; marine proteobacterial sortase target protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A9Z1V5.1 GenPept UniProtKB/Swiss-Prot:A9Z1V5

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