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Cldn22 claudin 22 [ Mus musculus (house mouse) ]

Gene ID: 75677, updated on 11-Apr-2024


Official Symbol
Cldn22provided by MGI
Official Full Name
claudin 22provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000038064 AllianceGenome:MGI:1922927
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210404A22Rik; 5330431C14Rik; 9530051B05Rik
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the Wwc2 gene (GeneID: 52357) on the opposite strand. [provided by RefSeq, Aug 2010]
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Genomic context

8 B1.1; 8 26.91 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (48277501..48278511)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (47824482..47825475)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700061N14 gene Neighboring gene claudin 24 Neighboring gene WW, C2 and coiled-coil domain containing 2 Neighboring gene predicted gene, 39173 Neighboring gene STARR-seq mESC enhancer starr_21422 Neighboring gene predicted gene, 31984

Genomic regions, transcripts, and products

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029383.2NP_083659.1  claudin-22

    See identical proteins and their annotated locations for NP_083659.1

    Status: VALIDATED

    Source sequence(s)
    Consensus CDS
    ENSMUSP00000041676.7, ENSMUST00000038693.8
    Conserved Domains (1) summary
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000074.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)