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Dusp9 dual specificity phosphatase 9 [ Mus musculus (house mouse) ]

Gene ID: 75590, updated on 8-Dec-2022

Summary

Official Symbol
Dusp9provided by MGI
Official Full Name
dual specificity phosphatase 9provided by MGI
Primary source
MGI:MGI:2387107
See related
Ensembl:ENSMUSG00000031383 AllianceGenome:MGI:2387107
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpk4; Pyst3
Summary
Enables MAP kinase tyrosine/serine/threonine phosphatase activity. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Orthologous to human DUSP9 (dual specificity phosphatase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 192.2), liver E14.5 (RPKM 17.2) and 1 other tissue See more
Orthologs
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Genomic context

See Dusp9 in Genome Data Viewer
Location:
X; X A7.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72682995..72687120)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73639389..73643514)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ATPase, Ca++ transporting, plasma membrane 3 Neighboring gene cyclin Q, pseudogene 1 Neighboring gene predicted gene, 46680 Neighboring gene predicted gene, 52444 Neighboring gene pregnancy upregulated non-ubiquitously expressed CaM kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 9
Names
dual-specificity MAP kinase phosphatase 4
NP_083628.3
XP_006528394.1
XP_006528396.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029352.3NP_083628.3  dual specificity protein phosphatase 9

    See identical proteins and their annotated locations for NP_083628.3

    Status: PROVISIONAL

    Source sequence(s)
    AY316312
    Consensus CDS
    CCDS30206.1
    UniProtKB/TrEMBL
    Q7TNL7
    Related
    ENSMUSP00000019701.9, ENSMUST00000019701.9
    Conserved Domains (3) summary
    COG2453
    Location:251410
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:272409
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cl00125
    Location:5206
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72682995..72687120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528333.1XP_006528396.1  dual specificity protein phosphatase 9 isoform X2

    See identical proteins and their annotated locations for XP_006528396.1

    Conserved Domains (2) summary
    cd01446
    Location:5190
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14566
    Location:256392
    DSP_MKP_classII; dual specificity phosphatase domain of class II mitogen-activated protein kinase phosphatase
  2. XM_006528331.1XP_006528394.1  dual specificity protein phosphatase 9 isoform X1

    Conserved Domains (2) summary
    cd14566
    Location:260396
    DSP_MKP_classII; dual specificity phosphatase domain of class II mitogen-activated protein kinase phosphatase
    cl00125
    Location:5194
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...