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Dynlrb2 dynein light chain roadblock-type 2 [ Mus musculus (house mouse) ]

Gene ID: 75465, updated on 8-May-2024

Summary

Official Symbol
Dynlrb2provided by MGI
Official Full Name
dynein light chain roadblock-type 2provided by MGI
Primary source
MGI:MGI:1922715
See related
Ensembl:ENSMUSG00000034467 AllianceGenome:MGI:1922715
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DNLC2B; Dncl2b; 1700009A04Rik
Summary
Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Part of cytoplasmic dynein complex. Is expressed in 4th ventricle; choroid plexus; lateral ventricle choroid plexus; lung; and retina. Orthologous to human DYNLRB2 (dynein light chain roadblock-type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 68.2), lung adult (RPKM 17.8) and 1 other tissue See more
Orthologs
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Genomic context

See Dynlrb2 in Genome Data Viewer
Location:
8 E1; 8 63.07 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (117231754..117242654)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (116505015..116515915)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:119028691-119028992 Neighboring gene NDC80 homolog, kinetochore complex component pseudogene Neighboring gene STARR-seq mESC enhancer starr_22798 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene predicted gene, 39258 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119111671-119111780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119114162-119114494 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119114548-119114808 Neighboring gene chromodomain protein, Y chromosome-like 2 Neighboring gene predicted gene, 31367

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein light chain roadblock-type 2
Names
dynein light chain 2B, cytoplasmic
dynein, cytoplasmic, light chain 2B
dynein, cytoplasmic, light polypeptide 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029297.1NP_083573.1  dynein light chain roadblock-type 2

    See identical proteins and their annotated locations for NP_083573.1

    Status: PROVISIONAL

    Source sequence(s)
    AK005789
    Consensus CDS
    CCDS40487.1
    UniProtKB/Swiss-Prot
    Q9DAJ5
    Related
    ENSMUSP00000077301.6, ENSMUST00000078170.7
    Conserved Domains (1) summary
    pfam03259
    Location:393
    Robl_LC7; Roadblock/LC7 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    117231754..117242654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)