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Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 [ Mus musculus (house mouse) ]

Gene ID: 75406, updated on 3-Nov-2024

Summary

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Official Symbol
Ndufs7provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase core subunit S7provided by MGI
Primary source
MGI:MGI:1922656
See related
Ensembl:ENSMUSG00000020153 AllianceGenome:MGI:1922656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CI-20kD; 1010001M04Rik
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity and protease binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; integumental system; respiratory system; retina; and urinary system. Human ortholog(s) of this gene implicated in developmental disorder of mental health and nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 322.2), duodenum adult (RPKM 296.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ndufs7 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80084939..80092628)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80249105..80256794)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3898 Neighboring gene PWWP domain containing 3A, DNA repair factor Neighboring gene nuclear encoded tRNA pheylalanine 3 (anticodon GAA) Neighboring gene nuclear encoded tRNA asparagine 7 (anticodon GTT) Neighboring gene STARR-positive B cell enhancer ABC_E5153 Neighboring gene STARR-positive B cell enhancer ABC_E10627 Neighboring gene guanidinoacetate methyltransferase Neighboring gene DAZ associated protein 1 Neighboring gene microRNA 6911

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13. Hyslop SJ, et al. Genomics, 1996 Nov 1. PMID 8938450
  2. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
  3. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
  4. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article
  5. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADH dehydrogenase (ubiquinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to NADH dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to NADH dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in electron transport coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Names
NADH dehydrogenase (ubiquinone) Fe-S protein 7
NADH-ubiquinone oxidoreductase 20 kDa subunit
complex I-20kD
NP_001351623.1
NP_083548.1
XP_006514333.1
XP_030101204.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364694.1 → NP_001351623.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC140229
    Conserved Domains (1) summary
    PRK06411
    Location:74 → 192
    PRK06411; NADH dehydrogenase subunit B; Validated

  2. NM_029272.4 → NP_083548.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_083548.1

    Status: VALIDATED

    Source sequence(s)
    AC140229
    Consensus CDS
    CCDS24015.1
    UniProtKB/Swiss-Prot
    Q9DC70
    Related
    ENSMUSP00000020361.7, ENSMUST00000020361.7
    Conserved Domains (1) summary
    PRK06411
    Location:74 → 224
    PRK06411; NADH-quinone oxidoreductase subunit NuoB

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80084939..80092628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514270.2 → XP_006514333.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK06411
    Location:46 → 196
    PRK06411; NADH-quinone oxidoreductase subunit NuoB

  2. XM_030245344.2 → XP_030101204.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9DC70
    Related
    ENSMUSP00000101003.2, ENSMUST00000105364.8
    Conserved Domains (1) summary
    PRK06411
    Location:74 → 224
    PRK06411; NADH-quinone oxidoreductase subunit NuoB
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC70.1 GenPept UniProtKB/Swiss-Prot:Q9DC70

Gene LinkOut

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