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Boll boule homolog, RNA binding protein [ Mus musculus (house mouse) ]

Gene ID: 75388, updated on 12-May-2024

Summary

Official Symbol
Bollprovided by MGI
Official Full Name
boule homolog, RNA binding proteinprovided by MGI
Primary source
MGI:MGI:1922638
See related
Ensembl:ENSMUSG00000025977 AllianceGenome:MGI:1922638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930554P13Rik; 4930597B14Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity and translation activator activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and positive regulation of translational initiation. Predicted to act upstream of or within meiotic cell cycle. Predicted to be located in several cellular components, including Flemming body; cytosol; and fibrillar center. Predicted to be active in cytoplasm. Is expressed in brain; central nervous system ganglion; germ cell of gonad; and olfactory epithelium. Orthologous to human BOLL (boule homolog, RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 18.9) See more
Orthologs
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Genomic context

Location:
1 C1.2; 1 28.08 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55282725..55402948, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (55243566..55363789, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene raftlin family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E4316 Neighboring gene predicted gene 10561 Neighboring gene STARR-seq mESC enhancer starr_00956 Neighboring gene methionine-tRNA synthetase 2 (mitochondrial) Neighboring gene STARR-seq mESC enhancer starr_00957 Neighboring gene predicted gene 8292 Neighboring gene basic transcription factor 3, pseudogene 17 Neighboring gene STARR-positive B cell enhancer mm9_chr1:55461214-55461515 Neighboring gene predicted gene 8531 Neighboring gene phospholipase C-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein boule-like
Names
bol, boule-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113367.3NP_001106838.1  protein boule-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122223
    Consensus CDS
    CCDS48261.1
    UniProtKB/TrEMBL
    E9PWH1, F7CFY0
    Related
    ENSMUSP00000110066.4, ENSMUST00000114423.7
  2. NM_001367887.2NP_001354816.1  protein boule-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122223
    UniProtKB/TrEMBL
    G3UYE8
    Related
    ENSMUSP00000134054.2, ENSMUST00000173983.8
  3. NM_001368767.1NP_001355696.1  protein boule-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122223
    UniProtKB/TrEMBL
    G3UYE8
    Conserved Domains (2) summary
    TIGR01628
    Location:45293
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12673
    Location:43123
    RRM_BOULE; RNA recognition motif in protein BOULE
  4. NM_001368768.1NP_001355697.1  protein boule-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122223
    Consensus CDS
    CCDS48261.1
    UniProtKB/TrEMBL
    E9PWH1, F7CFY0
  5. NM_029267.5NP_083543.2  protein boule-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122223
    Consensus CDS
    CCDS48262.1
    UniProtKB/Swiss-Prot
    E9QPQ9, Q924M5, Q9D4V2
    UniProtKB/TrEMBL
    G3UYE8
    Related
    ENSMUSP00000084868.4, ENSMUST00000087585.10
    Conserved Domains (2) summary
    TIGR01628
    Location:45283
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12673
    Location:43123
    RRM_BOULE; RNA recognition motif (RRM) found in protein BOULE

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    55282725..55402948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_373267.4 RNA Sequence