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Rnf19b ring finger protein 19B [ Mus musculus (house mouse) ]

Gene ID: 75234, updated on 26-Sep-2022

Summary

Official Symbol
Rnf19bprovided by MGI
Official Full Name
ring finger protein 19Bprovided by MGI
Primary source
MGI:MGI:1922484
See related
Ensembl:ENSMUSG00000028793 AllianceGenome:MGI:1922484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ibrdc3; 4930534K13Rik; 4930555L03Rik
Summary
Predicted to enable ubiquitin binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Acts upstream of or within natural killer cell mediated cytotoxicity. Located in cytolytic granule. Orthologous to human RNF19B (ring finger protein 19B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 168.3), ovary adult (RPKM 52.6) and 22 other tissues See more
Orthologs
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Genomic context

See Rnf19b in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128951871..128978319)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129058144..129084526)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene antizyme inhibitor 2 Neighboring gene predicted gene 15904 Neighboring gene adenylate kinase 2 Neighboring gene RIKEN cDNA 1700086P04 gene Neighboring gene transmembrane protein 54 Neighboring gene hippocalcin Neighboring gene fibronectin type III domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytolytic granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytolytic granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF19B
Names
IBR domain containing 3
IBR domain-containing protein 3
natural killer lytic-associated molecule
NP_001355692.1
NP_083495.1
XP_036020406.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368763.1NP_001355692.1  E3 ubiquitin-protein ligase RNF19B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS89829.1
    UniProtKB/Swiss-Prot
    Q7TT05
    Related
    ENSMUSP00000030584.5, ENSMUST00000030584.11
    Conserved Domains (4) summary
    smart00647
    Location:184248
    IBR; In Between Ring fingers
    pfam01485
    Location:280318
    IBR; IBR domain, a half RING-finger domain
    cd16776
    Location:116169
    RING-HC_RBR_RNF19B; RING finger, HC subclass, found in RING finger protein 19B (RNF19B) and similar proteins
    cl00570
    Location:344433
    AzlC; AzlC protein
  2. NM_029219.2NP_083495.1  E3 ubiquitin-protein ligase RNF19B isoform 2

    See identical proteins and their annotated locations for NP_083495.1

    Status: VALIDATED

    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS51305.1
    UniProtKB/TrEMBL
    E9Q2L7
    Related
    ENSMUSP00000131373.2, ENSMUST00000168461.8
    Conserved Domains (4) summary
    smart00647
    Location:184248
    IBR; In Between Ring fingers
    pfam01485
    Location:279317
    IBR; IBR domain, a half RING-finger domain
    pfam13639
    Location:116163
    zf-RING_2; Ring finger domain
    cl00570
    Location:343432
    AzlC; AzlC protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    128951871..128978319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164513.1XP_036020406.1  E3 ubiquitin-protein ligase RNF19B isoform X1