bbc3 BCL2 binding component 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bbc3provided by ZNC
Official Full Name: BCL2 binding component 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-070119-4
See related: Ensembl:ENSDARG00000069282 AllianceGenome:ZFIN:ZDB-GENE-070119-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Acts upstream of or within several processes, including cellular response to ionizing radiation; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in mitochondrion. Is expressed in several structures, including central nervous system; head; heart; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human BBC3 (BCL2 binding component 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (23745217..23761613, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (23809952..23826371, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis.
Title: Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis.
Bad functions as an essential sensitizer and Puma as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.
Title: Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis.
Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation
Title: Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to ionizing radiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bcl-2-binding component 3

Names: Puma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045472.2 → NP_001038937.1 bcl-2-binding component 3

See identical proteins and their annotated locations for NP_001038937.1

Status: PROVISIONAL

Source sequence(s)

BC139508

UniProtKB/TrEMBL

Q0GKC9

Conserved Domains (1) summary

pfam15826
Location:26 → 169

PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

23745217..23761613 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009291674.4 → XP_009289949.1 bcl-2-binding component 3 isoform X1

UniProtKB/TrEMBL

A0A8M3AHE7, F1QKA1

Related

ENSDARP00000118542.1, ENSDART00000137918.3

Conserved Domains (1) summary

pfam15826
Location:26 → 169

PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis