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XG Xg glycoprotein (Xg blood group) [ Homo sapiens (human) ]

Gene ID: 7499, updated on 22-Sep-2022

Summary

Official Symbol
XGprovided by HGNC
Official Full Name
Xg glycoprotein (Xg blood group)provided by HGNC
Primary source
HGNC:HGNC:12806
See related
Ensembl:ENSG00000124343 MIM:300879; AllianceGenome:HGNC:12806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PBDX
Summary
This gene encodes the XG blood group antigen, and is located at the pseudoautosomal boundary on the short (p) arm of chromosome X. The three 5' exons reside in the pseudoautosomal region and the remaining exons within the X-specific end. A truncated copy of this gene is found on the Y chromosome at the pseudoautosomal boundary. It is transcribed, but not expected to make a Y-chromosome specific gene product. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Expression
Biased expression in skin (RPKM 8.7), fat (RPKM 4.1) and 4 other tissues See more
Orthologs
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Genomic context

Location:
Xp22.33
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (2752040..2816500)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (2365029..2429443)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (2670081..2734541)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 102 Neighboring gene CD99 molecule pseudogene 1 Neighboring gene CD99 molecule (Xg blood group) Neighboring gene glycogenin 2 Neighboring gene ARSD antisense RNA 1 Neighboring gene arylsulfatase D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Homology

Clone Names

  • MGC118758, MGC118759, MGC118760, MGC118761

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in T cell extravasation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in biological_process ND
No biological Data available
more info
 
involved_in homotypic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of neutrophil extravasation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glycoprotein Xg
Names
Xg blood group (pseudoautosomal boundary-divided on the X chromosome)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011627.1 RefSeqGene

    Range
    4989..69449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_805

mRNA and Protein(s)

  1. NM_001141919.2NP_001135391.1  glycoprotein Xg isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame coding exon compared to transcript variant 1. This results in a longer isoform (2) with a 15 aa segment not found in isoform 1.
    Source sequence(s)
    AC006209, AC138085, AF380356, AK304164, BX098030, BX379565
    Consensus CDS
    CCDS48073.1
    UniProtKB/Swiss-Prot
    P55808
    UniProtKB/TrEMBL
    B4E289
    Related
    ENSP00000494087.1, ENST00000644266.2
  2. NM_001141920.2NP_001135392.1  glycoprotein Xg isoform 3 precursor

    See identical proteins and their annotated locations for NP_001135392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate donor splice site at one of the coding exons compared to transcript variant 1, resulting in an isoform (3) containing one additional aa compared to isoform 1.
    Source sequence(s)
    AC006209, AC138085, AF380356, AK304164, BC100767, BX098030, BX379565
    UniProtKB/Swiss-Prot
    P55808
    UniProtKB/TrEMBL
    B4E289
  3. NM_175569.3NP_780778.1  glycoprotein Xg isoform 1 precursor

    See identical proteins and their annotated locations for NP_780778.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AC006209, AC138085, AF380356, AK304164, BX098030, BX379565
    Consensus CDS
    CCDS14120.1
    UniProtKB/Swiss-Prot
    P55808, Q71BZ5
    UniProtKB/TrEMBL
    B4E289
    Related
    ENSP00000370566.5, ENST00000381174.10

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    2752040..2816500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274587.5XP_005274644.1  glycoprotein Xg isoform X1

  2. XM_011545575.4XP_011543877.1  glycoprotein Xg isoform X3

  3. XM_017029787.3XP_016885276.1  glycoprotein Xg isoform X2

    Related
    ENSP00000411004.3, ENST00000419513.7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    2365029..2429443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)