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Wipi2 WD repeat domain, phosphoinositide interacting 2 [ Mus musculus (house mouse) ]

Gene ID: 74781, updated on 30-Apr-2024

Summary

Official Symbol
Wipi2provided by MGI
Official Full Name
WD repeat domain, phosphoinositide interacting 2provided by MGI
Primary source
MGI:MGI:1923831
See related
Ensembl:ENSMUSG00000029578 AllianceGenome:MGI:1923831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110018O08Rik; 2510001I10Rik
Summary
Enables phosphatidylinositol-3-phosphate binding activity. Acts upstream of or within protein lipidation involved in autophagosome assembly; protein localization to phagophore assembly site; and xenophagy. Located in autophagosome and phagophore assembly site. Is expressed in cranial ganglion; dorsal root ganglion; submandibular gland primordium; telencephalon; and vibrissa epidermal component. Orthologous to human WIPI2 (WD repeat domain, phosphoinositide interacting 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 25.2), adrenal adult (RPKM 22.3) and 28 other tissues See more
Orthologs
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Genomic context

See Wipi2 in Genome Data Viewer
Location:
5 G2; 5 81.53 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142615269..142655427)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142629533..142669672)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E10363 Neighboring gene predicted gene, 31274 Neighboring gene STARR-seq mESC enhancer starr_14752 Neighboring gene predicted gene, 40352 Neighboring gene solute carrier family 29 (nucleoside transporters), member 4 Neighboring gene trinucleotide repeat containing 18 Neighboring gene STARR-seq mESC enhancer starr_14754 Neighboring gene predicted gene, 31365

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein lipidation involved in autophagosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein localization to phagophore assembly site IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in protein localization to phagophore assembly site ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within xenophagy IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagophore assembly site membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
WD repeat domain phosphoinositide-interacting protein 2
Names
WIPI-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417864.1NP_001404793.1  WD repeat domain phosphoinositide-interacting protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105987, AC158310
  2. NM_178398.5NP_848485.1  WD repeat domain phosphoinositide-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_848485.1

    Status: VALIDATED

    Source sequence(s)
    AC105987, AC158310
    Consensus CDS
    CCDS19828.1
    UniProtKB/Swiss-Prot
    Q80W47
    UniProtKB/TrEMBL
    D3YWK1
    Related
    ENSMUSP00000045201.10, ENSMUST00000036872.16
    Conserved Domains (2) summary
    COG2319
    Location:21272
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:143182
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    142615269..142655427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165568.1XP_036021461.1  WD repeat domain phosphoinositide-interacting protein 2 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:1050
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:5167
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...