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Ppa2 pyrophosphatase (inorganic) 2 [ Mus musculus (house mouse) ]

Gene ID: 74776, updated on 8-Jan-2023

Summary

Official Symbol
Ppa2provided by MGI
Official Full Name
pyrophosphatase (inorganic) 2provided by MGI
Primary source
MGI:MGI:1922026
See related
Ensembl:ENSMUSG00000028013 AllianceGenome:MGI:1922026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sid6306; 1110013G13Rik
Summary
Enables protein serine/threonine phosphatase activity. Predicted to be involved in diphosphate metabolic process; phosphate-containing compound metabolic process; and regulation of mitochondrial membrane potential. Located in mitochondrion. Orthologous to human PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 80.8), kidney adult (RPKM 69.5) and 28 other tissues See more
Orthologs
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Genomic context

See Ppa2 in Genome Data Viewer
Location:
3; 3 G3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (133015842..133083996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (133310059..133378235)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene integrator complex subunit 12 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 38 Neighboring gene predicted gene, 52616 Neighboring gene tet methylcytosine dioxygenase 2 Neighboring gene predicted gene 49316

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC6539

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables inorganic diphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inorganic diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in diphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphate-containing compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inorganic pyrophosphatase 2, mitochondrial
Names
PPase 2
pyrophosphate phospho-hydrolase 2
NP_001280570.1
NP_666253.1
XP_006502279.1
XP_006502280.1
XP_030108717.1
XP_030108718.1
XP_036019259.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293641.1NP_001280570.1  inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA444705, AC125040, AK090384
    Consensus CDS
    CCDS80024.1
    UniProtKB/Swiss-Prot
    Q91VM9
    UniProtKB/TrEMBL
    D3Z636
    Related
    ENSMUSP00000113369.2, ENSMUST00000122334.8
    Conserved Domains (1) summary
    cl00217
    Location:3284
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
  2. NM_146141.2NP_666253.1  inorganic pyrophosphatase 2, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_666253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA444705, AK090384, AK143475
    Consensus CDS
    CCDS17850.1
    UniProtKB/Swiss-Prot
    Q91VM9, Q9D1E3
    Related
    ENSMUSP00000029644.10, ENSMUST00000029644.16
    Conserved Domains (1) summary
    cl00217
    Location:3284
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    133015842..133083996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163366.1XP_036019259.1  inorganic pyrophosphatase 2, mitochondrial isoform X1

  2. XM_006502216.5XP_006502279.1  inorganic pyrophosphatase 2, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00217
    Location:3226
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
  3. XM_030252857.2XP_030108717.1  inorganic pyrophosphatase 2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00217
    Location:3226
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
  4. XM_006502217.5XP_006502280.1  inorganic pyrophosphatase 2, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00217
    Location:26167
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
  5. XM_030252858.2XP_030108718.1  inorganic pyrophosphatase 2, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl00217
    Location:26167
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.