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Ddit4 DNA-damage-inducible transcript 4 [ Mus musculus (house mouse) ]

Gene ID: 74747, updated on 26-Sep-2021

Summary

Official Symbol
Ddit4provided by MGI
Official Full Name
DNA-damage-inducible transcript 4provided by MGI
Primary source
MGI:MGI:1921997
See related
Ensembl:ENSMUSG00000020108
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dig; REDD; Rtp8; dig2; REDD1; Rtp801; AA415483; 5830413E08Rik
Expression
Ubiquitous expression in spleen adult (RPKM 71.7), adrenal adult (RPKM 65.1) and 26 other tissues See more
Orthologs
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Genomic context

See Ddit4 in Genome Data Viewer
Location:
10; 10 B4
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59785497..59787592, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59949675..59951770, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (59412423..59414518, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B12 Neighboring gene predicted gene, 46226 Neighboring gene predicted gene, 40673 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene predicted gene, 51801 Neighboring gene sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein-containing complex disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA damage-inducible transcript 4 protein
Names
HIF-1 responsive RTP801
HIF-1 responsive protein RTP801
REDD-1
dexamethasone-induced gene 2 protein
protein regulated in development and DNA damage response 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029083.2NP_083359.1  DNA damage-inducible transcript 4 protein

    See identical proteins and their annotated locations for NP_083359.1

    Status: PROVISIONAL

    Source sequence(s)
    AK017926
    Consensus CDS
    CCDS23868.1
    UniProtKB/Swiss-Prot
    Q9D3F7
    UniProtKB/TrEMBL
    B7ZNP9
    Related
    ENSMUSP00000020308.4, ENSMUST00000020308.5
    Conserved Domains (1) summary
    pfam07809
    Location:101220
    RTP801_C; RTP801 C-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    59785497..59787592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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