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Pcf11 PCF11 cleavage and polyadenylation factor subunit [ Mus musculus (house mouse) ]

Gene ID: 74737, updated on 11-Apr-2024

Summary

Official Symbol
Pcf11provided by MGI
Official Full Name
PCF11 cleavage and polyadenylation factor subunitprovided by MGI
Primary source
MGI:MGI:1919579
See related
Ensembl:ENSMUSG00000041328 AllianceGenome:MGI:1919579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2500001H09Rik; 5730417B17Rik
Summary
Predicted to enable RNA polymerase II complex binding activity and mRNA binding activity. Predicted to be involved in mRNA polyadenylation and termination of RNA polymerase II transcription. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of mRNA cleavage factor complex. Predicted to be active in cytoplasm. Orthologous to human PCF11 (PCF11 cleavage and polyadenylation factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.7), CNS E11.5 (RPKM 7.9) and 28 other tissues See more
Orthologs
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Genomic context

See Pcf11 in Genome Data Viewer
Location:
7 E1; 7 51.56 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (92292666..92319284, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (92643458..92670080, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31491 Neighboring gene coiled-coil domain containing 90B Neighboring gene ankyrin repeat domain 42 Neighboring gene STARR-positive B cell enhancer ABC_E6571 Neighboring gene predicted gene, 26944 Neighboring gene STARR-positive B cell enhancer ABC_E291 Neighboring gene STARR-seq mESC enhancer starr_19528 Neighboring gene pantothenate kinase 1 pseudogene Neighboring gene predicted gene 2551

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

General gene information

Markers

Clone Names

  • KIAA0824

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in termination of RNA polymerase II transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in termination of RNA polymerase II transcription ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mRNA cleavage factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pre-mRNA cleavage complex 2 protein Pcf11
Names
cleavage and polyadenylation factor subunit homolog
pre-mRNA cleavage complex II protein Pcf11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029078.3NP_083354.3  pre-mRNA cleavage complex 2 protein Pcf11

    See identical proteins and their annotated locations for NP_083354.3

    Status: VALIDATED

    Source sequence(s)
    AK173035, BC030492, CJ046746
    Consensus CDS
    CCDS52311.1
    UniProtKB/Swiss-Prot
    B2RX07, F6UFZ5, G3X9Z4, Q3TT32, Q3TTQ0, Q69ZY3, Q8K0S1, Q8R2P5, Q99KH9
    UniProtKB/TrEMBL
    A5HLW1
    Related
    ENSMUSP00000113717.2, ENSMUST00000119954.9
    Conserved Domains (1) summary
    cd03562
    Location:19130
    CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    92292666..92319284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508272.5XP_006508335.1  pre-mRNA cleavage complex 2 protein Pcf11 isoform X1

    UniProtKB/TrEMBL
    A0A9S4HM55
    Related
    ENSMUSP00000115278.2, ENSMUST00000151177.2
    Conserved Domains (3) summary
    PTZ00121
    Location:311471
    PTZ00121; MAEBL; Provisional
    pfam09606
    Location:9811328
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16982
    Location:19145
    CID_Pcf11; CID (CTD-Interacting Domain) of Pcf11