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Abcb8 ATP-binding cassette, sub-family B member 8 [ Mus musculus (house mouse) ]

Gene ID: 74610, updated on 8-Feb-2024

Summary

Official Symbol
Abcb8provided by MGI
Official Full Name
ATP-binding cassette, sub-family B member 8provided by MGI
Primary source
MGI:MGI:1351667
See related
Ensembl:ENSMUSG00000028973 AllianceGenome:MGI:1351667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MITOSUR; 4833412N02Rik
Summary
Predicted to enable ATP binding activity and ATPase-coupled transmembrane transporter activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; respiratory system; retina; and urinary system. Orthologous to human ABCB8 (ATP binding cassette subfamily B member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 40.2), heart adult (RPKM 32.8) and 28 other tissues See more
Orthologs
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Genomic context

See Abcb8 in Genome Data Viewer
Location:
5 A3; 5 11.57 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24598679..24617757)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24393681..24412759)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15589 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:23853089-23853272 Neighboring gene STARR-positive B cell enhancer ABC_E10309 Neighboring gene nitric oxide synthase 3, endothelial cell Neighboring gene STARR-positive B cell enhancer ABC_E4747 Neighboring gene STARR-positive B cell enhancer ABC_E1677 Neighboring gene autophagy related 9B Neighboring gene cyclin dependent kinase 5 Neighboring gene STARR-positive B cell enhancer ABC_E9251 Neighboring gene acid-sensing ion channel 3 Neighboring gene solute carrier family 4 (anion exchanger), member 2 Neighboring gene predicted gene, 22333

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type peptide transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of mitochondrial ATP-gated potassium channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mitochondrial ATP-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitochondrial potassium channel ATP-binding subunit
Names
ATP-binding cassette sub-family B member 8, mitochondrial
ATP-binding cassette, sub-family B (MDR/TAP), member 8
mitochondrial sulfonylurea-receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029020.3NP_083296.2  mitochondrial potassium channel ATP-binding subunit precursor

    See identical proteins and their annotated locations for NP_083296.2

    Status: VALIDATED

    Source sequence(s)
    AC113055
    Consensus CDS
    CCDS19118.1
    UniProtKB/Swiss-Prot
    Q8C695, Q8C7W4, Q9CXJ4
    Related
    ENSMUSP00000072826.6, ENSMUST00000073076.12
    Conserved Domains (1) summary
    COG1132
    Location:116695
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24598679..24617757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249790.3XP_011248092.1  mitochondrial potassium channel ATP-binding subunit isoform X2

    Conserved Domains (3) summary
    cd03249
    Location:184422
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    cd07346
    Location:352
    ABC_6TM_exporters; TM helix 4 [structural motif]
    cl38913
    Location:1157
    ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
  2. XM_006535812.1XP_006535875.1  mitochondrial potassium channel ATP-binding subunit isoform X1

    See identical proteins and their annotated locations for XP_006535875.1

    UniProtKB/Swiss-Prot
    Q8C695, Q8C7W4, Q9CXJ4
    Related
    ENSMUSP00000110729.2, ENSMUST00000115077.8
    Conserved Domains (1) summary
    COG1132
    Location:116695
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]