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WIPF1 WAS/WASL interacting protein family member 1 [ Homo sapiens (human) ]

Gene ID: 7456, updated on 5-Sep-2021

Summary

Official Symbol
WIPF1provided by HGNC
Official Full Name
WAS/WASL interacting protein family member 1provided by HGNC
Primary source
HGNC:HGNC:12736
See related
Ensembl:ENSG00000115935 MIM:602357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WIP; WAS2; PRPL-2; WASPIP
Summary
This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 61.9), appendix (RPKM 50.1) and 23 other tissues See more
Orthologs
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Genomic context

See WIPF1 in Genome Data Viewer
Location:
2q31.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (174559574..174682913, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175424302..175547641, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RPA3 pseudogene 1 Neighboring gene RNA, U6 small nuclear 5, pseudogene Neighboring gene RNA, U7 small nuclear 44 pseudogene Neighboring gene H3 histone pseudogene 6 Neighboring gene cholinergic receptor nicotinic alpha 1 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables profilin binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WAS/WASL-interacting protein family member 1
Names
WASP-interacting protein
Wiskott-Aldrich syndrome protein interacting protein
protein PRPL-2
testicular tissue protein Li 226

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032009.1 RefSeqGene

    Range
    5001..128326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_374

mRNA and Protein(s)

  1. NM_001077269.1NP_001070737.1  WAS/WASL-interacting protein family member 1 isoform a

    See identical proteins and their annotated locations for NP_001070737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3-5, encodes isoform a.
    Source sequence(s)
    AA903457, AL529597, AL832275, BC002914, BC045584, BC110288, BM475558, BX640870
    Consensus CDS
    CCDS2260.1
    UniProtKB/Swiss-Prot
    O43516
    UniProtKB/TrEMBL
    A0A140VJZ9, Q2YDC4
    Related
    ENSP00000352802.3, ENST00000359761.7
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  2. NM_001375832.1NP_001362761.1  WAS/WASL-interacting protein family member 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 2, 4, and 5, encodes isoform a.
    Source sequence(s)
    AC010894
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  3. NM_001375833.1NP_001362762.1  WAS/WASL-interacting protein family member 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3 and 5, encodes isoform a.
    Source sequence(s)
    AC010894
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  4. NM_001375834.1NP_001362763.1  WAS/WASL-interacting protein family member 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4, encodes isoform a.
    Source sequence(s)
    AC010894
    Related
    ENSP00000503603.1, ENST00000679041.1
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  5. NM_001375835.1NP_001362764.1  WAS/WASL-interacting protein family member 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (b).
    Source sequence(s)
    AC010894, AC104595
    Related
    ENSP00000272746.5, ENST00000272746.9
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  6. NM_001375836.1NP_001362765.1  WAS/WASL-interacting protein family member 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 8 and 9, encodes isoform c.
    Source sequence(s)
    AC010894, AC104595
    Related
    ENSP00000387150.3, ENST00000409415.7
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  7. NM_001375837.1NP_001362766.1  WAS/WASL-interacting protein family member 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 7 and 9, encodes isoform c.
    Source sequence(s)
    AC010894
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  8. NM_001375838.1NP_001362767.1  WAS/WASL-interacting protein family member 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 7 and 8, encodes isoform c.
    Source sequence(s)
    AC010894
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  9. NM_001375839.1NP_001362768.1  WAS/WASL-interacting protein family member 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC010894
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  10. NM_003387.5NP_003378.3  WAS/WASL-interacting protein family member 1 isoform a

    See identical proteins and their annotated locations for NP_003378.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2-5, encodes isoform a.
    Source sequence(s)
    AC010894
    Consensus CDS
    CCDS2260.1
    UniProtKB/Swiss-Prot
    O43516
    UniProtKB/TrEMBL
    A0A140VJZ9, Q2YDC4
    Related
    ENSP00000376330.2, ENST00000392547.6
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    174559574..174682913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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