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WIPF1 WAS/WASL interacting protein family member 1 [ Homo sapiens (human) ]

Gene ID: 7456, updated on 11-Sep-2019

Summary

Official Symbol
WIPF1provided by HGNC
Official Full Name
WAS/WASL interacting protein family member 1provided by HGNC
Primary source
HGNC:HGNC:12736
See related
Ensembl:ENSG00000115935 MIM:602357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WIP; WAS2; PRPL-2; WASPIP
Summary
This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 61.9), appendix (RPKM 50.1) and 23 other tissues See more
Orthologs

Genomic context

See WIPF1 in Genome Data Viewer
Location:
2q31.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (174559574..174682899, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175424302..175547667, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene replication protein A3, 14kDa pseudogene Neighboring gene RNA, U6 small nuclear 5, pseudogene Neighboring gene RNA, U7 small nuclear 44 pseudogene Neighboring gene H3 histone pseudogene 6 Neighboring gene cholinergic receptor nicotinic alpha 1 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
    Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
    Fc-epsilon receptor I signaling in mast cells
  • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
    Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate WASPs and WAVEs, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate WASPs and WAVEs, organism-specific biosystemWASP and WAVE proteins belong to the Wiskott-Aldrich Syndrome protein family, with recessive mutations in the founding member WASP being responsible for the X-linked recessive immunodeficieny known a...
  • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
    Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin binding TAS
Traceable Author Statement
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
profilin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
actin cortical patch assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cortical patch localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin polymerization or depolymerization TAS
Traceable Author Statement
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
response to other organism IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WAS/WASL-interacting protein family member 1
Names
WASP-interacting protein
Wiskott-Aldrich syndrome protein interacting protein
protein PRPL-2
testicular tissue protein Li 226

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032009.1 RefSeqGene

    Range
    5001..128326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_374

mRNA and Protein(s)

  1. NM_001077269.1NP_001070737.1  WAS/WASL-interacting protein family member 1

    See identical proteins and their annotated locations for NP_001070737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA903457, AL529597, AL832275, BC002914, BC045584, BC110288, BM475558, BX640870
    Consensus CDS
    CCDS2260.1
    UniProtKB/Swiss-Prot
    O43516
    UniProtKB/TrEMBL
    A0A140VJZ9, Q2YDC4
    Related
    ENSP00000352802.3, ENST00000359761.7
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
  2. NM_003387.5NP_003378.3  WAS/WASL-interacting protein family member 1

    See identical proteins and their annotated locations for NP_003378.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010894
    Consensus CDS
    CCDS2260.1
    UniProtKB/Swiss-Prot
    O43516
    UniProtKB/TrEMBL
    A0A140VJZ9, Q2YDC4
    Related
    ENSP00000376330.2, ENST00000392547.6
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    174559574..174682899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511780.3XP_011510082.1  WAS/WASL-interacting protein family member 1 isoform X1

    See identical proteins and their annotated locations for XP_011510082.1

    UniProtKB/Swiss-Prot
    O43516
    UniProtKB/TrEMBL
    A0A140VJZ9
    Related
    ENSP00000376329.2, ENST00000392546.6
    Conserved Domains (1) summary
    pfam02205
    Location:3155
    WH2; WH2 motif
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