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Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 74551, updated on 5-Mar-2024

Summary

Official Symbol
Pck2provided by MGI
Official Full Name
phosphoenolpyruvate carboxykinase 2 (mitochondrial)provided by MGI
Primary source
MGI:MGI:1860456
See related
Ensembl:ENSMUSG00000040618 AllianceGenome:MGI:1860456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEPCK-M; 1810010O14Rik; 9130022B02Rik
Summary
Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to be involved in several processes, including cellular response to hormone stimulus; gluconeogenesis; and monocarboxylic acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 31.2), spleen adult (RPKM 15.0) and 26 other tissues See more
Orthologs
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Genomic context

See Pck2 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55777721..55787477)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55540263..55550020)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene copine VI Neighboring gene neural retina leucine zipper gene Neighboring gene STARR-positive B cell enhancer ABC_E10826 Neighboring gene STARR-positive B cell enhancer ABC_E5439 Neighboring gene STARR-seq mESC enhancer starr_36772 Neighboring gene STARR-positive B cell enhancer ABC_E607 Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene fat storage-inducing transmembrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoenolpyruvate carboxykinase (GTP) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoenolpyruvate carboxykinase (GTP) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoenolpyruvate carboxykinase (GTP) activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoenolpyruvate carboxykinase activity ISO
Inferred from Sequence Orthology
more info
 
enables purine nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NADH oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dexamethasone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gluconeogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in glycerol biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hepatocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in oxaloacetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in propionate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyruvate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphoenolpyruvate carboxykinase [GTP], mitochondrial
Names
phosphoenolpyruvate carboxylase
NP_083270.2
XP_030103944.1
XP_030103945.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028994.3NP_083270.2  phosphoenolpyruvate carboxykinase [GTP], mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AK030501, BU757365
    Consensus CDS
    CCDS27114.2
    UniProtKB/Swiss-Prot
    Q8BH04, Q8BMM9, Q91Z10
    UniProtKB/TrEMBL
    Q3TDE6
    Related
    ENSMUSP00000038555.4, ENSMUST00000048781.4
    Conserved Domains (1) summary
    cd00819
    Location:44633
    PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55777721..55787477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248084.2XP_030103944.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q3UQD8
    Conserved Domains (1) summary
    cl22860
    Location:1350
    PEPCK_HprK; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...
  2. XM_030248085.2XP_030103945.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q3UQD8
    Conserved Domains (1) summary
    cl22860
    Location:1350
    PEPCK_HprK; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...